3v60: Difference between revisions

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-[[Image:3v60.jpg|left|200px]]
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+==Structure of S. cerevisiae PCNA conjugated to SUMO on lysine 164==
-The line below this paragraph, containing "STRUCTURE_3v60", creates the "Structure Box" on the page.
+<StructureSection load='3v60' size='340' side='right'caption='[[3v60]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3v60]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V60 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3V60 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-{{STRUCTURE_3v60|  PDB=3v60  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3v60 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3v60 OCA], [https://pdbe.org/3v60 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3v60 RCSB], [https://www.ebi.ac.uk/pdbsum/3v60 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3v60 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/SMT3_YEAST SMT3_YEAST] Not known; suppressor of MIF2 mutations.
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Ubiquitin (Ub) and ubiquitin-like (Ubl) modifiers such as SUMO (also known as Smt3 in Saccharomyces cerevisiae) mediate signal transduction through post-translational modification of substrate proteins in pathways that control differentiation, apoptosis and the cell cycle, and responses to stress such as the DNA damage response. In yeast, the proliferating cell nuclear antigen PCNA (also known as Pol30) is modified by ubiquitin in response to DNA damage and by SUMO during S phase. Whereas Ub-PCNA can signal for recruitment of translesion DNA polymerases, SUMO-PCNA signals for recruitment of the anti-recombinogenic DNA helicase Srs2. It remains unclear how receptors such as Srs2 specifically recognize substrates after conjugation to Ub and Ubls. Here we show, through structural, biochemical and functional studies, that the Srs2 carboxy-terminal domain harbours tandem receptor motifs that interact independently with PCNA and SUMO and that both motifs are required to recognize SUMO-PCNA specifically. The mechanism presented is pertinent to understanding how other receptors specifically recognize Ub- and Ubl-modified substrates to facilitate signal transduction.
-===Structure of S. cerevisiae PCNA conjugated to SUMO on lysine 164===
+Recognition of SUMO-modified PCNA requires tandem receptor motifs in Srs2.,Armstrong AA, Mohideen F, Lima CD Nature. 2012 Feb 29;483(7387):59-63. doi: 10.1038/nature10883. PMID:22382979<ref>PMID:22382979</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 3v60" style="background-color:#fffaf0;"></div>
-==About this Structure==
+==See Also==
-[[3v60]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3V60 OCA].
+*[[Proliferating cell nuclear antigen 3D structures|Proliferating cell nuclear antigen 3D structures]]
-[[Category: Saccharomyces cerevisiae]]
+*[[SUMO 3D Structures|SUMO 3D Structures]]
-[[Category: Armstrong, A A.]]
+== References ==
-[[Category: Lima, C D.]]
+<references/>
-[[Category: Mohideen, F.]]
+__TOC__
-[[Category: Nuclear]]
+</StructureSection>
-[[Category: Post-translational modification dna replication dna damage response]]
+[[Category: Large Structures]]
-[[Category: Protein binding-dna binding protein complex]]
+[[Category: Saccharomyces cerevisiae S288C]]
-[[Category: Srs2]]
+[[Category: Armstrong AA]]
-[[Category: Ubiquitin-like protein pcna]]
+[[Category: Lima CD]]
+[[Category: Mohideen F]]