Glucose-dependent Insulinotropic Polypeptide Receptor: Difference between revisions
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===Introduction=== | ===Introduction=== | ||
'''Glucose-dependent insulinotropic polypeptide receptor''' (GIPR) is a transmembrane protein which is responsible for boosting glucose-induced insulin production. The transcription of this protein is positively controlled by glucose molecules; GIPR is expressed in higher levels when glucose is in higher concentration. The receptor is a multispan membrane-bound protein (shown in blue) consisting of an alpha helix, half twist helices, and beta sheets bound in several locations with disulfide bonds within itself. The ligand which binds to GIPR is glucose-dependent insulinotropic polypeptide (GIP), also known as gastric inhibitory polypeptide (shown in green). GIP is an alpha helical endogenous polypeptide [[Hormone|hormone]] which is released upon the ingestion of food, specifically the carbohydrate glucose. | '''Glucose-dependent insulinotropic polypeptide receptor''' or '''gastric inhibitory polypeptide receptor''' (GIPR) is a transmembrane protein which is responsible for boosting glucose-induced insulin production. The transcription of this protein is positively controlled by glucose molecules; GIPR is expressed in higher levels when glucose is in higher concentration. The receptor is a multispan membrane-bound protein (shown in blue) consisting of an alpha helix, half twist helices, and beta sheets bound in several locations with disulfide bonds within itself. The ligand which binds to GIPR is glucose-dependent insulinotropic polypeptide (GIP), also known as gastric inhibitory polypeptide (shown in green). GIP is an alpha helical endogenous polypeptide [[Hormone|hormone]] which is released upon the ingestion of food, specifically the carbohydrate glucose. | ||
===Molecular Function=== | ===Molecular Function=== | ||
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}} | ||
[[2qkh]] - | [[7fiy]] – hGDIPR (mutant) + gastric inhibitory polypeptide + guanine nucleotide-binding protein – human – Cryo EM<br /> | ||
[[7ra3]], [[7rbt]] – hGDIPR + gastric inhibitory polypeptide + guanine nucleotide-binding protein + nanobody + ScfV – Cryo EM<br /> | |||
[[7dty]], [[7fin]], [[7vab]] – hGDIPR (mutant) + gastric inhibitory polypeptide + guanine nucleotide-binding protein + nanobody – Cryo EM<br /> | |||
[[2qkh]] - hGDIPR extracellular domain 29-138 + GIP <br /> | |||
[[4hj0]], [[6dkj]] - hGDIPR extracellular domain + antibody <br /> | |||
[[6o9h]], [[6o9i]] - mGDIPR extracellular domain + antibody - mouse <br /> | |||
===References=== | ===References=== | ||