3u74: Difference between revisions

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 ==Crystal structure of stabilized human uPAR mutant==
-<StructureSection load='3u74' size='340' side='right' caption='[[3u74]], [[Resolution|resolution]] 2.39&Aring;' scene=''>
+<StructureSection load='3u74' size='340' side='right'caption='[[3u74]], [[Resolution|resolution]] 2.39&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[3u74]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U74 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3U74 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[3u74]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U74 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U74 FirstGlance]. <br>
-</td></tr><tr><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene><br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.39&#8491;</td></tr>
-<tr><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2fat|2fat]], [[3bt1|3bt1]], [[3bt2|3bt2]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
-<tr><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">MO3, PLAUR, UPAR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u74 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u74 OCA], [https://pdbe.org/3u74 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u74 RCSB], [https://www.ebi.ac.uk/pdbsum/3u74 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u74 ProSAT]</span></td></tr>
-<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u74 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u74 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3u74 RCSB], [http://www.ebi.ac.uk/pdbsum/3u74 PDBsum]</span></td></tr>
+</table>
-<table>
+== Function ==
+[https://www.uniprot.org/uniprot/UPAR_HUMAN UPAR_HUMAN] Acts as a receptor for urokinase plasminogen activator. Plays a role in localizing and promoting plasmin formation. Mediates the proteolysis-independent signal transduction activation effects of U-PA. It is subject to negative-feedback regulation by U-PA which cleaves it into an inactive form.
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 14: / Line 16: @@
 Crystal structure of the urokinase receptor in a ligand-free form.,Xu X, Gardsvoll H, Yuan C, Lin L, Ploug M, Huang M J Mol Biol. 2012 Mar 9;416(5):629-41. Epub 2012 Jan 21. PMID:22285761<ref>PMID:22285761</ref>
-From MEDLINEÂ®/PubMedÂ®, a database of the U.S. National Library of Medicine.<br>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 3u74" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Urokinase plasminogen activator surface receptor 3D structures|Urokinase plasminogen activator surface receptor 3D structures]]
 == References ==
 <references/>
@@ Line 21: / Line 27: @@
 </StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Huang, M D.]]
+[[Category: Large Structures]]
-[[Category: Xu, X.]]
+[[Category: Huang MD]]
-[[Category: Yuan, C.]]
+[[Category: Xu X]]
-[[Category: Glycosylation]]
+[[Category: Yuan C]]
-[[Category: Hydrolase receptor]]