3u3s: Difference between revisions

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<StructureSection load='3u3s' size='340' side='right'caption='[[3u3s]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
<StructureSection load='3u3s' size='340' side='right'caption='[[3u3s]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3u3s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U3S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U3S FirstGlance]. <br>
<table><tr><td colspan='2'>[[3u3s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U3S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U3S FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3u3p|3u3p]], [[3u3q|3u3q]], [[3u3t|3u3t]], [[3u3v|3u3v]]</div></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">TNFRSF21, DR6, UNQ437/PRO868 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u3s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u3s OCA], [https://pdbe.org/3u3s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u3s RCSB], [https://www.ebi.ac.uk/pdbsum/3u3s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u3s ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u3s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u3s OCA], [https://pdbe.org/3u3s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u3s RCSB], [https://www.ebi.ac.uk/pdbsum/3u3s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u3s ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/TNR21_HUMAN TNR21_HUMAN]] May activate NF-kappa-B and promote apoptosis. May activate JNK and be involved in T-cell differentiation. Required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).  
[https://www.uniprot.org/uniprot/TNR21_HUMAN TNR21_HUMAN] May activate NF-kappa-B and promote apoptosis. May activate JNK and be involved in T-cell differentiation. Required for both normal cell body death and axonal pruning. Trophic-factor deprivation triggers the cleavage of surface APP by beta-secretase to release sAPP-beta which is further cleaved to release an N-terminal fragment of APP (N-APP). N-APP binds TNFRSF21 triggering caspase activation and degeneration of both neuronal cell bodies (via caspase-3) and axons (via caspase-6).
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Ding, W]]
[[Category: Ding W]]
[[Category: Hung, L W]]
[[Category: Hung LW]]
[[Category: Jiao, L Y]]
[[Category: Jiao LY]]
[[Category: Liu, Z J]]
[[Category: Liu ZJ]]
[[Category: Matsugaki, N]]
[[Category: Matsugaki N]]
[[Category: Ru, H]]
[[Category: Ru H]]
[[Category: Shaw, N]]
[[Category: Shaw N]]
[[Category: Wakatsuki, S]]
[[Category: Wakatsuki S]]
[[Category: Zhang, L G]]
[[Category: Zhang LG]]
[[Category: Zhao, L X]]
[[Category: Zhao LX]]
[[Category: Apoptosis]]
[[Category: Trigger apoptosis]]

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