3u3n: Difference between revisions

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 <StructureSection load='3u3n' size='340' side='right'caption='[[3u3n]], [[Resolution|resolution]] 1.65&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[3u3n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Horsefly Horsefly]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U3N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U3N FirstGlance]. <br>
+<table><tr><td colspan='2'>[[3u3n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Tabanus_yao Tabanus yao]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U3N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U3N FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene>, <scene name='pdbligand=PR:PRASEODYMIUM+ION'>PR</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.651&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3u3u|3u3u]], [[3u31|3u31]]</div></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=PLM:PALMITIC+ACID'>PLM</scene>, <scene name='pdbligand=PR:PRASEODYMIUM+ION'>PR</scene></td></tr>
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u3n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u3n OCA], [https://pdbe.org/3u3n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u3n RCSB], [https://www.ebi.ac.uk/pdbsum/3u3n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u3n ProSAT]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/LYSF_TABYA LYSF_TABYA] Anti-inflammatory scavenger of eicosanoids and antithrombotic protein that inhibits platelets aggregation induced by collagen, ADP and convulxin (GPVI agonist) (PubMed:21475772, PubMed:22311975). Exhibits high affinity binding for glycoprotein IIb-IIIa receptor (ITGA2B/ITGB3) and endothelial cell alphaVbeta3 (ITGAV/ITGB3) integrins, but not for alpha-5/beta-1 or alpha-2/beta-1 (PubMed:21475772). Accordingly, it blocks endothelial cell adhesion to vitronectin (IC(50)~1 nM) and marginally to fibronectin (IC(50)~1 uM), but not to collagen (PubMed:21475772). It also inhibits fibroblast growth factor (FGF)-induced endothelial cell proliferation, and attenuates tube formation in vitro (PubMed:21475772). In addition, it dose-dependently attenuates thrombus formation to collagen under flow (PubMed:21475772). Also binds proinflammatory cysteinyl leukotrienes (leukotrienes C4 (LTC4), D4 (LTD4) and E4 (LTE4)) with submicromolar affinities (PubMed:22311975).<ref>PMID:21475772</ref> <ref>PMID:22311975</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
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 __TOC__
 </StructureSection>
-[[Category: Horsefly]]
 [[Category: Large Structures]]
-[[Category: Andersen, J F]]
+[[Category: Tabanus yao]]
-[[Category: Alphavbeta3 integrin]]
+[[Category: Andersen JF]]
-[[Category: Binding protein]]
-[[Category: Cap domain]]
-[[Category: Protein binding]]
-[[Category: Salivary gland]]