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==Crystal Structure of the tRNA modifier TiaS from Pyrococcus furiosus, Northeast Structural Genomics Consortium Target PfR225==
==Crystal Structure of the tRNA modifier TiaS from Pyrococcus furiosus, Northeast Structural Genomics Consortium Target PfR225==
<StructureSection load='3u02' size='340' side='right' caption='[[3u02]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='3u02' size='340' side='right'caption='[[3u02]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3u02]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Pyrfu Pyrfu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U02 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3U02 FirstGlance]. <br>
<table><tr><td colspan='2'>[[3u02]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_furiosus_DSM_3638 Pyrococcus furiosus DSM 3638]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U02 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3U02 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.399&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PF1855 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=186497 PYRFU])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3u02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u02 OCA], [https://pdbe.org/3u02 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3u02 RCSB], [https://www.ebi.ac.uk/pdbsum/3u02 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3u02 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u02 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u02 OCA], [http://pdbe.org/3u02 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3u02 RCSB], [http://www.ebi.ac.uk/pdbsum/3u02 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3u02 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/Q8TZX0_PYRFU Q8TZX0_PYRFU]] ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA (By similarity).[HAMAP-Rule:MF_01892]  
[https://www.uniprot.org/uniprot/Q8TZX0_PYRFU Q8TZX0_PYRFU] ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA (By similarity).[HAMAP-Rule:MF_01892]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Pyrfu]]
[[Category: Large Structures]]
[[Category: Acton, T B]]
[[Category: Pyrococcus furiosus DSM 3638]]
[[Category: Ciccosanti, C]]
[[Category: Acton TB]]
[[Category: Everett, J K]]
[[Category: Ciccosanti C]]
[[Category: Hunt, J F]]
[[Category: Everett JK]]
[[Category: Kuzin, A]]
[[Category: Hunt JF]]
[[Category: Lew, S]]
[[Category: Kuzin A]]
[[Category: Montelione, G T]]
[[Category: Lew S]]
[[Category: Structural genomic]]
[[Category: Montelione GT]]
[[Category: Nair, R]]
[[Category: Nair R]]
[[Category: Rost, B]]
[[Category: Rost B]]
[[Category: Sahdev, S]]
[[Category: Sahdev S]]
[[Category: Seetharaman, J]]
[[Category: Seetharaman J]]
[[Category: Tong, L]]
[[Category: Tong L]]
[[Category: Wang, H]]
[[Category: Wang H]]
[[Category: Xiao, R]]
[[Category: Xiao R]]
[[Category: Nesg]]
[[Category: PSI, Protein structure initiative]]
[[Category: Psi-biology]]
[[Category: Transcription]]

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