Ficolin: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

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-{{STRUCTURE_2j64|  PDB=2j64  | SIZE=400| SCENE= |right|CAPTION=Human H-ficolin binding domain trimer complex with Ca+2 ion, [[2j64]] }}
+<StructureSection load='2j64' size='350' side='right' scene='46/466464/Cv/1' caption='Human H-ficolin binding domain trimer complex with Ca+2 ion (PDB code [[2j64]]) '>
-'''Ficolin''' (Fic) are defense proteins which belong to the innate immune system and recognize carbohydrate molecules.  3 ficolins were identified in humans L-Fic, H-Fic and M-Fic.
+== Function ==
+'''Ficolin''' (Fic) are defense proteins which belong to the innate immune system and recognize carbohydrate molecules<ref>PMID:9777405</ref>.  3 ficolins were identified in humans '''L-Fic''' or '''ficolin-2''', '''H-Fic''' or '''ficolin-3''' and '''M-Fic''' or '''ficolin-1'''.
+*'''Fiicolin-1''' or '''M-ficolin''' is a pattern recognition molecule of the complement system expressed in myeloid cells<ref>PMID:18343499</ref>.
+== Disease ==
+Fn may play a role in inflammatory diseases, apoptosis, lupus, preeclampsia and IgA nephropathy<ref>PMID:19025118</ref>.
+== Structural highlights ==
+<scene name='46/466464/Cv/4'>Human H-ficolin binding domain trimer</scene>.
+<scene name='46/466464/Cv/5'>Ca coordination site</scene> (PDB code [[2j64]]).<ref>PMID:17215869</ref> Water molecules shown as red spheres.
+</StructureSection>
 == 3D Structures of Ficolin ==
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+== References ==
+<references/>