Ficolin: Difference between revisions

Latest revision as of 11:00, 23 June 2024

Function

Ficolin (Fic) are defense proteins which belong to the innate immune system and recognize carbohydrate molecules^[1]. 3 ficolins were identified in humans L-Fic or ficolin-2, H-Fic or ficolin-3 and M-Fic or ficolin-1.

Fiicolin-1 or M-ficolin is a pattern recognition molecule of the complement system expressed in myeloid cells^[2].

Disease

Fn may play a role in inflammatory diseases, apoptosis, lupus, preeclampsia and IgA nephropathy^[3].

Structural highlights

.

(PDB code 2j64).^[4] Water molecules shown as red spheres.

Human H-ficolin binding domain trimer complex with Ca+2 ion (PDB code 2j64)

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3D Structures of Ficolin3D Structures of Ficolin

Updated on 23-June-2024

ReferencesReferences

↑ Lu J, Le Y. Ficolins and the fibrinogen-like domain. Immunobiology. 1998 Aug;199(2):190-9. PMID:9777405 doi:http://dx.doi.org/10.1016/S0171-2985(98)80026-0
↑ Honoré C, Rørvig S, Munthe-Fog L, Hummelshøj T, Madsen HO, Borregaard N, Garred P. The innate pattern recognition molecule Ficolin-1 is secreted by monocytes/macrophages and is circulating in human plasma. Mol Immunol. 2008 May;45(10):2782-9. PMID:18343499 doi:10.1016/j.molimm.2008.02.005
↑ Zhang XL, Ali MA. Ficolins: structure, function and associated diseases. Adv Exp Med Biol. 2008;632:105-15. PMID:19025118
↑ Garlatti V, Belloy N, Martin L, Lacroix M, Matsushita M, Endo Y, Fujita T, Fontecilla-Camps JC, Arlaud GJ, Thielens NM, Gaboriaud C. Structural insights into the innate immune recognition specificities of L- and H-ficolins. EMBO J. 2007 Jan 24;26(2):623-33. Epub 2007 Jan 11. PMID:17215869

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

[1] Lu J, Le Y. Ficolins and the fibrinogen-like domain. Immunobiology. 1998 Aug;199(2):190-9. PMID:9777405 doi:http://dx.doi.org/10.1016/S0171-2985(98)80026-0

[2] Honoré C, Rørvig S, Munthe-Fog L, Hummelshøj T, Madsen HO, Borregaard N, Garred P. The innate pattern recognition molecule Ficolin-1 is secreted by monocytes/macrophages and is circulating in human plasma. Mol Immunol. 2008 May;45(10):2782-9. PMID:18343499 doi:10.1016/j.molimm.2008.02.005

[3] Zhang XL, Ali MA. Ficolins: structure, function and associated diseases. Adv Exp Med Biol. 2008;632:105-15. PMID:19025118

[4] Garlatti V, Belloy N, Martin L, Lacroix M, Matsushita M, Endo Y, Fujita T, Fontecilla-Camps JC, Arlaud GJ, Thielens NM, Gaboriaud C. Structural insights into the innate immune recognition specificities of L- and H-ficolins. EMBO J. 2007 Jan 24;26(2):623-33. Epub 2007 Jan 11. PMID:17215869

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-{{STRUCTURE_2j64|  PDB=2j64  | SIZE=400| SCENE= |right|CAPTION=Human H-ficolin binding domain trimer complex with Ca+2 ion, [[2j64]] }}
+<StructureSection load='2j64' size='350' side='right' scene='46/466464/Cv/1' caption='Human H-ficolin binding domain trimer complex with Ca+2 ion (PDB code [[2j64]]) '>
-'''Ficolin''' (Fic) are defense proteins which belong to the innate immune system and recognize carbohydrate molecules.  3 ficolins were identified in humans L-Fic, H-Fic and M-Fic.
+== Function ==
-{{TOC limit|limit=2}}
+'''Ficolin''' (Fic) are defense proteins which belong to the innate immune system and recognize carbohydrate molecules<ref>PMID:9777405</ref>.  3 ficolins were identified in humans '''L-Fic''' or '''ficolin-2''', '''H-Fic''' or '''ficolin-3''' and '''M-Fic''' or '''ficolin-1'''.
+*'''Fiicolin-1''' or '''M-ficolin''' is a pattern recognition molecule of the complement system expressed in myeloid cells<ref>PMID:18343499</ref>.
-== 3D Structures of Ficoln ==
+== Disease ==
-===H-ficolin===
+Fn may play a role in inflammatory diseases, apoptosis, lupus, preeclampsia and IgA nephropathy<ref>PMID:19025118</ref>.
-[[2j64]] - hH-Fic binding domain - human<br />
+== Structural highlights ==
-[[2j5z]] - hH-Fic binding domain + galactose<br />
-[[2j60]] - hH-Fic binding domain + fucose<br />
-[[2j61]] - hH-Fic binding domain + acetyl-glucosamine<br />
-===L-ficolin===
+<scene name='46/466464/Cv/4'>Human H-ficolin binding domain trimer</scene>.
-[[2j3g]] - hL-Fic binding domain<br />
+<scene name='46/466464/Cv/5'>Ca coordination site</scene> (PDB code [[2j64]]).<ref>PMID:17215869</ref> Water molecules shown as red spheres.
-[[2j0g]] – hL-Fic binding domain + N-acetyl-mannosamine<br />
+</StructureSection>
-[[2j0h]] - hL-Fic binding domain + acetylcholine<br />
+== 3D Structures of Ficolin ==
-[[2j0y]] - hL-Fic binding domain + glucan<br />
-[[2j1g]], [[2j2p]] - hL-Fic binding domain + acetylcysteine<br />
-[[2j3f]] - hL-Fic binding domain + galactosamine<br />
-[[2j3o]] - hL-Fic binding domain + acetyl-glucosamine<br />
-[[2j3u]] - hL-Fic binding domain + galactose<br />
-===M-ficolin===
+Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+{{#tree:id=OrganizedByTopic|openlevels=0|
-[[2d39]] – hM-Fic fibrinogen-like domain<br />
+*H-ficolin
-[[2wnp]] - hM-Fic fibrinogen-like domain (mutant) <br />
-[[2jhh]], [[2jhm]] – hM-Fic C terminal<br />
-[[2jhi]] - hL-Mic C terminal + acetyl-galactosamine<br />
-[[2jhk]] - hL-Mic C terminal + acetyl-glucosamine<br />
-[[2jhl]] - hL-Mic C terminal + sialic acid
+**[[2j64]] - hH-Fic binding domain - human<br />
+**[[2j5z]] - hH-Fic binding domain + galactose<br />
+**[[2j60]] - hH-Fic binding domain + fucose<br />
+**[[2j61]] - hH-Fic binding domain + acetyl-glucosamine<br />
+*L-ficolin
+**[[2j3g]], [[4r9t]] - hL-Fic binding domain<br />
+**[[2j0g]] – hL-Fic binding domain + N-acetyl-mannosamine<br />
+**[[2j0h]] - hL-Fic binding domain + acetylcholine<br />
+**[[4nyt]] - hL-Fic binding domain + phosphocholine<br />
+**[[2j0y]] - hL-Fic binding domain + glucan<br />
+**[[2j1g]], [[2j2p]] - hL-Fic binding domain + acetylcysteine<br />
+**[[2j3f]] - hL-Fic binding domain + galactosamine<br />
+**[[2j3o]] - hL-Fic binding domain + acetyl-glucosamine<br />
+**[[4r9j]] - hL-Fic binding domain + glucosamine sulfate<br />
+**[[2j3u]] - hL-Fic binding domain + galactose<br />
+*M-ficolin
+**[[2d39]] – hM-Fic fibrinogen-like domain<br />
+**[[2wnp]] - hM-Fic fibrinogen-like domain (mutant) <br />
+**[[2jhh]], [[2jhm]] – hM-Fic C terminal<br />
+**[[2jhi]] - hL-Mic C terminal + acetyl-galactosamine<br />
+**[[2jhk]] - hL-Mic C terminal + acetyl-glucosamine<br />
+**[[2jhl]] - hL-Mic C terminal + sialic acid
+}}
+== References ==
+<references/>