Ficolin: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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-{{STRUCTURE_2j0h|  PDB=2j0h  | SIZE=400| SCENE= |right|CAPTION=Human L-ficolin binding domain complex with galactosamine, [[2j0h]] }}
+<StructureSection load='2j64' size='350' side='right' scene='46/466464/Cv/1' caption='Human H-ficolin binding domain trimer complex with Ca+2 ion (PDB code [[2j64]]) '>
-'''Ficolin''' (Fic) are defense proteins which belong to the innate immune system and recognize carbohydrate molecules.  3 ficolins were identified in humans L-Fic, H-Fic and M-Fic.
+== Function ==
-{{TOC limit|limit=2}}
+'''Ficolin''' (Fic) are defense proteins which belong to the innate immune system and recognize carbohydrate molecules<ref>PMID:9777405</ref>.  3 ficolins were identified in humans '''L-Fic''' or '''ficolin-2''', '''H-Fic''' or '''ficolin-3''' and '''M-Fic''' or '''ficolin-1'''.
+*'''Fiicolin-1''' or '''M-ficolin''' is a pattern recognition molecule of the complement system expressed in myeloid cells<ref>PMID:18343499</ref>.
-== 3D Structures of Ficoln ==
+== Disease ==
+Fn may play a role in inflammatory diseases, apoptosis, lupus, preeclampsia and IgA nephropathy<ref>PMID:19025118</ref>.
+== Structural highlights ==
+<scene name='46/466464/Cv/4'>Human H-ficolin binding domain trimer</scene>.
+<scene name='46/466464/Cv/5'>Ca coordination site</scene> (PDB code [[2j64]]).<ref>PMID:17215869</ref> Water molecules shown as red spheres.
+</StructureSection>
+== 3D Structures of Ficolin ==
+Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+{{#tree:id=OrganizedByTopic|openlevels=0|
+*H-ficolin
+**[[2j64]] - hH-Fic binding domain - human<br />
+**[[2j5z]] - hH-Fic binding domain + galactose<br />
+**[[2j60]] - hH-Fic binding domain + fucose<br />
+**[[2j61]] - hH-Fic binding domain + acetyl-glucosamine<br />
+*L-ficolin
+**[[2j3g]], [[4r9t]] - hL-Fic binding domain<br />
+**[[2j0g]] – hL-Fic binding domain + N-acetyl-mannosamine<br />
+**[[2j0h]] - hL-Fic binding domain + acetylcholine<br />
+**[[4nyt]] - hL-Fic binding domain + phosphocholine<br />
+**[[2j0y]] - hL-Fic binding domain + glucan<br />
+**[[2j1g]], [[2j2p]] - hL-Fic binding domain + acetylcysteine<br />
+**[[2j3f]] - hL-Fic binding domain + galactosamine<br />
+**[[2j3o]] - hL-Fic binding domain + acetyl-glucosamine<br />
+**[[4r9j]] - hL-Fic binding domain + glucosamine sulfate<br />
+**[[2j3u]] - hL-Fic binding domain + galactose<br />
+*M-ficolin
+**[[2d39]] – hM-Fic fibrinogen-like domain<br />
+**[[2wnp]] - hM-Fic fibrinogen-like domain (mutant) <br />
+**[[2jhh]], [[2jhm]] – hM-Fic C terminal<br />
+**[[2jhi]] - hL-Mic C terminal + acetyl-galactosamine<br />
+**[[2jhk]] - hL-Mic C terminal + acetyl-glucosamine<br />
+**[[2jhl]] - hL-Mic C terminal + sialic acid
+}}
+== References ==
+<references/>