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==X-ray structure of mouse ribonuclease inhibitor complexed with mouse ribonuclease 1==
==X-ray structure of mouse ribonuclease inhibitor complexed with mouse ribonuclease 1==
<StructureSection load='3tsr' size='340' side='right' caption='[[3tsr]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='3tsr' size='340' side='right'caption='[[3tsr]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3tsr]] is a 8 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TSR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3TSR FirstGlance]. <br>
<table><tr><td colspan='2'>[[3tsr]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TSR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TSR FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1999&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Rib-1, Rib1, Rnase1, Rns1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), Rnh, Rnh1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tsr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tsr OCA], [https://pdbe.org/3tsr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tsr RCSB], [https://www.ebi.ac.uk/pdbsum/3tsr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tsr ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3tsr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tsr OCA], [http://pdbe.org/3tsr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3tsr RCSB], [http://www.ebi.ac.uk/pdbsum/3tsr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3tsr ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/RNAS1_MOUSE RNAS1_MOUSE]] Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single-stranded and double-stranded RNA (By similarity). [[http://www.uniprot.org/uniprot/RINI_MOUSE RINI_MOUSE]] Ribonuclease inhibitor which inhibits RNASE1, RNASE2 and ANG. May play a role in redox homeostasis (By similarity).  
[https://www.uniprot.org/uniprot/RNAS1_MOUSE RNAS1_MOUSE] Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single-stranded and double-stranded RNA (By similarity).
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== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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==See Also==
==See Also==
*[[Temp|Temp]]
*[[Ribonuclease 3D structures|Ribonuclease 3D structures]]
*[[Ribonuclease inhibitor|Ribonuclease inhibitor]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Lk3 transgenic mice]]
[[Category: Large Structures]]
[[Category: Pancreatic ribonuclease]]
[[Category: Mus musculus]]
[[Category: Bingman, C A]]
[[Category: Bingman CA]]
[[Category: Chang, A]]
[[Category: Chang A]]
[[Category: Lomax, J E]]
[[Category: Lomax JE]]
[[Category: Phillips, G N]]
[[Category: Phillips Jr GN]]
[[Category: Raines, R T]]
[[Category: Raines RT]]
[[Category: Hydrolase]]
[[Category: Hydrolase inhibitor]]
[[Category: Hydrolase-hydrolase inhibitor complex]]
[[Category: Leucine-rich repeat]]

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