3tjh: Difference between revisions

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-[[Image:3tjh.png|left|200px]]
-<!--
+==42F3-p3A1/H2-Ld complex==
-The line below this paragraph, containing "STRUCTURE_3tjh", creates the "Structure Box" on the page.
+<StructureSection load='3tjh' size='340' side='right'caption='[[3tjh]], [[Resolution|resolution]] 2.12&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3tjh]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TJH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3TJH FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.12&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3tjh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3tjh OCA], [https://pdbe.org/3tjh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3tjh RCSB], [https://www.ebi.ac.uk/pdbsum/3tjh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3tjh ProSAT]</span></td></tr>
-{{STRUCTURE_3tjh|  PDB=3tjh  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/HA1L_MOUSE HA1L_MOUSE] Involved in the presentation of foreign antigens to the immune system.
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+T cell receptor (TCR) engagement of peptide-major histocompatibility complex (pMHC) is essential to adaptive immunity, but it is unknown whether TCR signaling responses are influenced by the binding topology of the TCR-peptide-MHC complex. We developed yeast-displayed pMHC libraries that enabled us to identify new peptide sequences reactive with a single TCR. Structural analysis showed that four peptides bound to the TCR with distinct 3D and 2D affinities using entirely different binding chemistries. Three of the peptides that shared a common docking mode, where key TCR-MHC germline interactions are preserved, induced TCR signaling. The fourth peptide failed to induce signaling and was recognized in a substantially different TCR-MHC binding mode that apparently exceeded geometric tolerances compatible with signaling. We suggest that the stereotypical TCR-MHC docking paradigm evolved from productive signaling geometries and that TCR signaling can be modulated by peptides that are recognized in alternative TCR-pMHC binding orientations.
-===42F3-p3A1/H2-Ld complex===
+T Cell Receptor Signaling Is Limited by Docking Geometry to Peptide-Major Histocompatibility Complex.,Adams JJ, Narayanan S, Liu B, Birnbaum ME, Kruse AC, Bowerman NA, Chen W, Levin AM, Connolly JM, Zhu C, Kranz DM, Garcia KC Immunity. 2011 Nov 16. PMID:22101157<ref>PMID:22101157</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-<!--
+</div>
-The line below this paragraph, {{ABSTRACT_PUBMED_22101157}}, adds the Publication Abstract to the page
+<div class="pdbe-citations 3tjh" style="background-color:#fffaf0;"></div>
-(as it appears on PubMed at http://www.pubmed.gov), where 22101157 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_22101157}}
+__TOC__
+</StructureSection>
-==About this Structure==
+[[Category: Homo sapiens]]
-[[3tjh]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [http://en.wikipedia.org/wiki/Mus_musculus,_homo_sapiens Mus musculus, homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3TJH OCA].
+[[Category: Large Structures]]
-==Reference==
-<ref group="xtra">PMID:022101157</ref><references group="xtra"/>
 [[Category: Mus musculus]]
-[[Category: Mus musculus, homo sapiens]]
+[[Category: Adams JJ]]
-[[Category: Adams, J J.]]
+[[Category: Garcia KC]]
-[[Category: Garcia, K C.]]
+[[Category: Kranz DM]]
-[[Category: Kranz, D M.]]
+[[Category: Kruse A]]
-[[Category: Kruse, A.]]
-[[Category: Antigen recognition]]
-[[Category: Ig mhc]]
-[[Category: Immune system]]
-[[Category: Membrane receptor]]
-[[Category: Tcr-pmhc]]