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==Structure of human glutathione reductase complexed with pyocyanin, an agent with antimalarial activity==
==Structure of human glutathione reductase complexed with pyocyanin, an agent with antimalarial activity==
<StructureSection load='3sqp' size='340' side='right' caption='[[3sqp]], [[Resolution|resolution]] 2.21&Aring;' scene=''>
<StructureSection load='3sqp' size='340' side='right'caption='[[3sqp]], [[Resolution|resolution]] 2.21&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3sqp]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SQP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3SQP FirstGlance]. <br>
<table><tr><td colspan='2'>[[3sqp]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SQP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SQP FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3J8:5-METHYLPHENAZIN-1(5H)-ONE'>3J8</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.21&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Glutathione-disulfide_reductase Glutathione-disulfide reductase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.8.1.7 1.8.1.7] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3J8:5-METHYLPHENAZIN-1(5H)-ONE'>3J8</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3sqp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sqp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3sqp RCSB], [http://www.ebi.ac.uk/pdbsum/3sqp PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sqp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sqp OCA], [https://pdbe.org/3sqp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sqp RCSB], [https://www.ebi.ac.uk/pdbsum/3sqp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sqp ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GSHR_HUMAN GSHR_HUMAN] Maintains high levels of reduced glutathione in the cytosol.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 3sqp" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Glutathione-disulfide reductase]]
[[Category: Homo sapiens]]
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Fritz-Wolf, K]]
[[Category: Fritz-Wolf K]]
[[Category: Goebel, U]]
[[Category: Goebel U]]
[[Category: Koenig, I]]
[[Category: Koenig I]]
[[Category: Schirmer, R H]]
[[Category: Schirmer RH]]
[[Category: Alternative initiation]]
[[Category: Cellular reductant]]
[[Category: Flavoprotein]]
[[Category: Glutathione reductase]]
[[Category: Mitochondrion]]
[[Category: Oxidoreductase]]
[[Category: Oxidoreductase-antibiotic complex]]
[[Category: Phosphoprotein]]
[[Category: Plasmodium falciparum]]
[[Category: Pyocyanin]]
[[Category: Redox-active center]]
[[Category: Transit peptide]]

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