3sn6: Difference between revisions
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==Crystal structure of the beta2 adrenergic receptor-Gs protein complex== | ==Crystal structure of the beta2 adrenergic receptor-Gs protein complex== | ||
<StructureSection load='3sn6' size='340' side='right' caption='[[3sn6]], [[Resolution|resolution]] 3.20Å' scene=''> | <StructureSection load='3sn6' size='340' side='right'caption='[[3sn6]], [[Resolution|resolution]] 3.20Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3sn6]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SN6 OCA]. For a <b>guided tour on the structure components</b> use [ | <table><tr><td colspan='2'>[[3sn6]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus], [https://en.wikipedia.org/wiki/Escherichia_virus_T4 Escherichia virus T4], [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Lama_glama Lama glama] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3SN6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3SN6 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=P0G:8-[(1R)-2-{[1,1-DIMETHYL-2-(2-METHYLPHENYL)ETHYL]AMINO}-1-HYDROXYETHYL]-5-HYDROXY-2H-1,4-BENZOXAZIN-3(4H)-ONE'>P0G</scene | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=P0G:8-[(1R)-2-{[1,1-DIMETHYL-2-(2-METHYLPHENYL)ETHYL]AMINO}-1-HYDROXYETHYL]-5-HYDROXY-2H-1,4-BENZOXAZIN-3(4H)-ONE'>P0G</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3sn6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3sn6 OCA], [https://pdbe.org/3sn6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3sn6 RCSB], [https://www.ebi.ac.uk/pdbsum/3sn6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3sn6 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/GNAS2_BOVIN GNAS2_BOVIN] Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(s) protein is involved in hormonal regulation of adenylate cyclase: it activates the cyclase in response to beta-adrenergic stimuli. | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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==See Also== | ==See Also== | ||
*[[ | *[[Adrenergic receptor|Adrenergic receptor]] | ||
*[[ | *[[Adrenergic receptor 3D structures|Adrenergic receptor 3D structures]] | ||
*[[Antibody 3D structures|Antibody 3D structures]] | |||
*[[G protein-coupled receptor|G protein-coupled receptor]] | |||
*[[GTP-binding protein 3D structures|GTP-binding protein 3D structures]] | |||
*[[Hormone|Hormone]] | |||
*[[Lysozyme 3D structures|Lysozyme 3D structures]] | *[[Lysozyme 3D structures|Lysozyme 3D structures]] | ||
*[[ | *[[Neurotransmitters|Neurotransmitters]] | ||
*[[Transducin 3D structures|Transducin 3D structures]] | |||
*[[Transducin|Transducin | *[[3D structures of non-human antibody|3D structures of non-human antibody]] | ||
*[[3D structures of antibody|3D structures of antibody]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Bos taurus]] | ||
[[Category: | [[Category: Escherichia virus T4]] | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Lama glama]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Rattus norvegicus]] | ||
[[Category: | [[Category: Caffrey M]] | ||
[[Category: | [[Category: Calinski D]] | ||
[[Category: | [[Category: Chae PS]] | ||
[[Category: | [[Category: Chung KY]] | ||
[[Category: | [[Category: DeVree BT]] | ||
[[Category: | [[Category: Gellman SH]] | ||
[[Category: | [[Category: Kobilka BK]] | ||
[[Category: | [[Category: Kobilka TS]] | ||
[[Category: | [[Category: Kruse AC]] | ||
[[Category: | [[Category: Lyons JA]] | ||
[[Category: | [[Category: Mathiesen JM]] | ||
[[Category: | [[Category: Pardon E]] | ||
[[Category: | [[Category: Rasmussen SGF]] | ||
[[Category: | [[Category: Shah STA]] | ||
[[Category: Skiniotis G]] | |||
[[Category: G | [[Category: Steyaert J]] | ||
[[Category: | [[Category: Sunahara RK]] | ||
[[Category: | [[Category: Thian FS]] | ||
[[Category: | [[Category: Weis WI]] | ||
[[Category: | [[Category: Zou Y]] | ||
[[Category: | |||