3s37: Difference between revisions

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-[[Image:3s37.png|left|200px]]
-{{STRUCTURE_3s37|  PDB=3s37  |  SCENE=  }}
+==Structural basis for the function of two anti-VEGF receptor antibodies==
+<StructureSection load='3s37' size='340' side='right'caption='[[3s37]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[3s37]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S37 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3S37 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3s37 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3s37 OCA], [https://pdbe.org/3s37 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3s37 RCSB], [https://www.ebi.ac.uk/pdbsum/3s37 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3s37 ProSAT]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The anti-VEGF receptor 2 antibody IMC-1121B is a promising antiangiogenic drug being tested for treatment of breast and gastric cancer. We have determined the structure of the 1121B Fab fragment in complex with domain 3 of VEGFR2, as well as the structure of a different neutralizing anti-VEGFR2 antibody, 6.64, also in complex with VEGFR2 domain 3. The two Fab fragments bind at opposite ends of VEGFR2 domain 3; 1121B directly blocks VEGF binding, whereas 6.64 may prevent receptor dimerization by perturbing the domain 3:domain 4 interface. Mutagenesis reveals that residues essential for VEGF, 1121B, and 6.64 binding are nonoverlapping among the three contact patches.
-===Structural basis for the function of two anti-VEGF receptor antibodies===
+The Structural Basis for the Function of Two Anti-VEGF Receptor 2 Antibodies.,Franklin MC, Navarro EC, Wang Y, Patel S, Singh P, Zhang Y, Persaud K, Bari A, Griffith H, Shen L, Balderes P, Kussie P Structure. 2011 Aug 10;19(8):1097-107. PMID:21827946<ref>PMID:21827946</ref>
-{{ABSTRACT_PUBMED_21827946}}
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-==About this Structure==
+<div class="pdbe-citations 3s37" style="background-color:#fffaf0;"></div>
-[[3s37]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3S37 OCA].
 ==See Also==
-*[[Vascular Endothelial Growth Factor Receptor|Vascular Endothelial Growth Factor Receptor]]
+*[[3D structures of vascular endothelial growth factor receptor|3D structures of vascular endothelial growth factor receptor]]
+== References ==
-==Reference==
+<references/>
-<ref group="xtra">PMID:021827946</ref><references group="xtra"/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
+[[Category: Large Structures]]
 [[Category: Mus musculus]]
-[[Category: Receptor protein-tyrosine kinase]]
+[[Category: Franklin MC]]
-[[Category: Franklin, M C.]]
-[[Category: Antibody]]
-[[Category: Cancer]]
-[[Category: Immune system-transferase complex]]
-[[Category: Kdr]]
-[[Category: Vegf receptor]]