3ryc: Difference between revisions

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-[[Image:3ryc.jpg|left|200px]]
-<!--
+==Tubulin: RB3 stathmin-like domain complex==
-The line below this paragraph, containing "STRUCTURE_3ryc", creates the "Structure Box" on the page.
+<StructureSection load='3ryc' size='340' side='right'caption='[[3ryc]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3ryc]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Ovis_aries Ovis aries] and [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RYC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RYC FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACE:ACETYL+GROUP'>ACE</scene>, <scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
-{{STRUCTURE_3ryc|  PDB=3ryc  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ryc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ryc OCA], [https://pdbe.org/3ryc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ryc RCSB], [https://www.ebi.ac.uk/pdbsum/3ryc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ryc ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/D0VWZ0_SHEEP D0VWZ0_SHEEP] Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain (By similarity).[RuleBase:RU003505][SAAS:SAAS023123_004_019801]
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Tubulin alternates between a soluble curved structure and a microtubule straight conformation. GTP binding to alphabeta-tubulin is required for microtubule assembly, but whether this triggers conversion into a straighter structure is still debated. This is due, at least in part, to the lack of structural data for GTP-tubulin before assembly. Here, we report atomic-resolution crystal structures of soluble tubulin in the GDP and GTP nucleotide states in a complex with a stathmin-like domain. The structures differ locally in the neighborhood of the nucleotide. A loop movement in GTP-bound tubulin favors its recruitment to the ends of growing microtubules and facilitates its curved-to-straight transition, but this conversion has not proceeded yet. The data therefore argue for the conformational change toward the straight structure occurring as microtubule-specific contacts are established. They also suggest a model for the way the tubulin structure is modified in relation to microtubule assembly.
-===Tubulin: RB3 stathmin-like domain complex===
+The determinants that govern microtubule assembly from the atomic structure of GTP-tubulin.,Nawrotek A, Knossow M, Gigant B J Mol Biol. 2011 Sep 9;412(1):35-42. Epub 2011 Jul 23. PMID:21787788<ref>PMID:21787788</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 3ryc" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_21787788}}, adds the Publication Abstract to the page
+*[[Stathmin-4 3D structures|Stathmin-4 3D structures]]
-(as it appears on PubMed at http://www.pubmed.gov), where 21787788 is the PubMed ID number.
+*[[Tubulin 3D Structures|Tubulin 3D Structures]]
--->
+== References ==
-{{ABSTRACT_PUBMED_21787788}}
+<references/>
+__TOC__
-==About this Structure==
+</StructureSection>
-[[3ryc]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Ovis_aries Ovis aries] and [http://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RYC OCA].
+[[Category: Large Structures]]
-==Reference==
-<ref group="xtra">PMID:021787788</ref><references group="xtra"/>
 [[Category: Ovis aries]]
 [[Category: Rattus norvegicus]]
-[[Category: Gigant, B.]]
+[[Category: Gigant B]]
-[[Category: Knossow, M.]]
+[[Category: Knossow M]]
-[[Category: Nawrotek, A.]]
+[[Category: Nawrotek A]]
-[[Category: Alpha-tubulin]]
-[[Category: Beta-tubulin]]
-[[Category: Cell cycle]]
-[[Category: Gtpase]]
-[[Category: Microtubule]]
-[[Category: Stathmin s-tubulin]]
-[[Category: Subtilisin]]
-[[Category: Tubulin]]