2lc6: Difference between revisions

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-[[Image:2lc6.png|left|200px]]
-<!--
+==Solution structure of Par-6 Q144C/L164C==
-The line below this paragraph, containing "STRUCTURE_2lc6", creates the "Structure Box" on the page.
+<StructureSection load='2lc6' size='340' side='right'caption='[[2lc6]]' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2lc6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LC6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LC6 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lc6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lc6 OCA], [https://pdbe.org/2lc6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lc6 RCSB], [https://www.ebi.ac.uk/pdbsum/2lc6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lc6 ProSAT]</span></td></tr>
-{{STRUCTURE_2lc6|  PDB=2lc6  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/O97111_DROME O97111_DROME]
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Here, we report a novel mechanism of PDZ (PSD-95/Dlg/ZO-1) domain regulation that distorts a conserved element of PDZ ligand recognition. The polarity regulator Par-6 assembles a conserved multiprotein complex and is directly modulated by the Rho GTPase Cdc42. Cdc42 binds the adjacent Cdc42/Rac interactive binding (CRIB) and PDZ domains of Par-6, increasing C-terminal ligand binding affinity by 10-fold. By solving structures of the isolated PDZ domain and a disulfide-stabilized CRIB-PDZ, we detected a conformational switch that controls affinity by altering the configuration of the conserved "GLGF" loop. As a result, lysine 165 is displaced from the PDZ core by an adjacent hydrophobic residue, disrupting coordination of the PDZ ligand-binding cleft. Stabilization of the CRIB:PDZ interface restores K165 to its canonical location in the binding pocket. We conclude that a unique "dipeptide switch" in the Par-6 PDZ transmits a signal for allosteric activation to the ligand-binding pocket.
-===Solution structure of Par-6 Q144C/L164C===
+A Conformational Switch in the CRIB-PDZ Module of Par-6.,Whitney DS, Peterson FC, Volkman BF Structure. 2011 Nov 9;19(11):1711-22. PMID:22078569<ref>PMID:22078569</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-<!--
+</div>
-The line below this paragraph, {{ABSTRACT_PUBMED_22078569}}, adds the Publication Abstract to the page
+<div class="pdbe-citations 2lc6" style="background-color:#fffaf0;"></div>
-(as it appears on PubMed at http://www.pubmed.gov), where 22078569 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_22078569}}
+__TOC__
+</StructureSection>
-==About this Structure==
-[[2lc6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LC6 OCA].
-==Reference==
-<ref group="xtra">PMID:022078569</ref><references group="xtra"/>
 [[Category: Drosophila melanogaster]]
-[[Category: Peterson, F C.]]
+[[Category: Large Structures]]
-[[Category: Volkman, B F.]]
+[[Category: Peterson FC]]
-[[Category: Whitney, D S.]]
+[[Category: Volkman BF]]
-[[Category: Cdc42]]
+[[Category: Whitney DS]]
-[[Category: Cell adhesion]]
-[[Category: Crib]]
-[[Category: Pdz domain]]

2lc6: Difference between revisions

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