Glycoproteins B and D: Difference between revisions

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[[Image:2c3a.png|left|200px|thumb|Crystal Structure of Glycoprotein D, [[2c3a]]]]
<StructureSection load='2gum' size='350' side='right' caption='Herpes virus glycoprotein B trimer complex with Na+ ion (purple) (PDB entry [[2gum]])' scene=''>
{{STRUCTURE_2c3a|  PDB=2c3a  | SIZE=300| SCENE=Glycoproteins_B_and_D/Glycoprotein_d/1 |right|CAPTION=Herpes virus glycoprotein D complex with Zn, Na and Cl ions, [[2c3a]] }}


'''Glycoproteins B, D''' (gB, gD)  are components of the cell-entry complex of herpes viruses


{{TOC limit|limit=2}}






'''Glycoproteins B, D''' (gB, gD)  are components of the cell-entry complex of herpes viruses<ref>PMID:16840698</ref><ref>PMID:21980294</ref>.
*'''Glycoprotein B'''  is required after herpes simplex virus attachment but before the expression of viral proteins<ref>PMID:2839688</ref>.
*'''Glycoprotein D''' determines which cells can be infected by herpes simplex virus by binding to the cell receptors which mediate the viral entry<ref>PMID:15273289</ref>.






== 3D Structures of Glycoproteins B and D ==


===Glycoprotein B===


[[3nw8]], [[3nwa]], [[3nwd]], [[3nwf]] – gB extracellular domain (mutant) <br />
</StructureSection>
[[2gum]] - gB extracellular domain
== 3D Structures of Glycoproteins B and D ==
 
===Glycoprotein D===


[[2c3a]], [[2c36]] – gD<br />
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
[[1l2g]] – gD extracellular domain<br />
{{#tree:id=OrganizedByTopic|openlevels=0|
[[1jma]] – gD (mutant) + herpes virus entry mediator (mutant)


*Glycoprotein B


**[[6bm8]], [[5v2s]] – Hhv1gB – Human herpes virus 1<br />
**[[6z9m]] – Hhv1gB – Cryo EM<br />
**[[2gum]], [[4bom]] - Hhv1gB extracellular domain<br />
**[[3nw8]], [[3nwa]], [[3nwd]], [[3nwf]], [[4hsi]], [[4l1r]] – Hhv1gB extracellular domain 30-730 (mutant) <br />
**[[7uhz]], [[7ui0]] – Hhv1gB + antibody – Human alphaherpesvirus 1 – Cryo EM<br />
**[[6vn1]] – Hhv3gB + antibody – Human alphaherpesvirus 3 – Cryo EM<br />
**[[7k1s]] – Hhv3gB – Cryo EM<br />
**[[6vlk]] – Hhv3gB <br />
**[[7kdd]] – Hhv5gB + antibody – Human herpes virus 5 - Cryo EM<br />
**[[6uoe]] – Hhv5gB + antibody<br />
**[[7kdp]] – Hhv5gB + inhibitor – Cryo EM<br />
**[[6esc]], [[5ys6]] - ShvgB – Suid alphaherpesvirus 1<br />
**[[5ys2]] - ShvgB domain IV 62-148 546-700 <br />
**[[5zs0]] - ShvgB domain IV + antibody <br />
**[[4osn]] – hCVgB – human cytomegalovirus<br />
**[[5cxf]] – hCVgB (mutant)<br />
**[[4ot1]], [[5c6t]] – hCVgB + antibody<br />
**[[6vlk]] – gB – varicella-zoster virus<br />
**[[3fvc]] – EbvgB – Epstein-Barr virus <br />
**[[7fbi]] – EbvgB + antibody - Cryo EM<br />


*Glycoprotein D


**[[2c3a]], [[2c36]], [[1l2g]], [[4myv]] – Hhv1gD extracellular domain <br />
**[[4myv]] – Hhv2gD extracellular domain - Human herpes virus 2<br />
**[[5x5v]] – prv-gD – peudorabies virus<br />
**[[5x5w]] – prv-gD + nectin-1<br />
**[[1jma]] – Hhv1gD extracellular domain (mutant) + herpes virus entry mediator (mutant)<br />
**[[3sku]] – Hhv1gD extracellular domain + herpes virus entry mediator<br />
**[[3u82]], [[4myw]] – Hhv2gD extracellular domain + poliovirus receptor-related protein<br />
**[[3w9e]] – Hhv2gD + antibody<br />
**[[6ls9]] - bgD – bovine alphaherpesvirus 1<br />
**[[6lsa]] – bgD + nectin-1<br />
**[[6sqj]] - gD – equine alphaherpesvirus 1<br />
**[[6tm8]] - gD – equine alphaherpesvirus 4<br />
}}


== References ==
<references/>


[[Category:Topic Page]]
[[Category:Topic Page]]

Latest revision as of 10:52, 1 July 2024




Glycoproteins B, D (gB, gD) are components of the cell-entry complex of herpes viruses[1][2].

  • Glycoprotein B is required after herpes simplex virus attachment but before the expression of viral proteins[3].
  • Glycoprotein D determines which cells can be infected by herpes simplex virus by binding to the cell receptors which mediate the viral entry[4].




Herpes virus glycoprotein B trimer complex with Na+ ion (purple) (PDB entry 2gum)

Drag the structure with the mouse to rotate

3D Structures of Glycoproteins B and D3D Structures of Glycoproteins B and D

Updated on 01-July-2024

ReferencesReferences

  1. ↑ Heldwein EE, Lou H, Bender FC, Cohen GH, Eisenberg RJ, Harrison SC. Crystal structure of glycoprotein B from herpes simplex virus 1. Science. 2006 Jul 14;313(5784):217-20. PMID:16840698 doi:313/5784/217
  2. ↑ Di Giovine P, Settembre EC, Bhargava AK, Luftig MA, Lou H, Cohen GH, Eisenberg RJ, Krummenacher C, Carfi A. Structure of herpes simplex virus glycoprotein d bound to the human receptor nectin-1. PLoS Pathog. 2011 Sep;7(9):e1002277. Epub 2011 Sep 29. PMID:21980294 doi:10.1371/journal.ppat.1002277
  3. ↑ Cai WH, Gu B, Person S. Role of glycoprotein B of herpes simplex virus type 1 in viral entry and cell fusion. J Virol. 1988 Aug;62(8):2596-604. PMID:2839688 doi:10.1128/JVI.62.8.2596-2604.1988
  4. ↑ Manoj S, Jogger CR, Myscofski D, Yoon M, Spear PG. Mutations in herpes simplex virus glycoprotein D that prevent cell entry via nectins and alter cell tropism. Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12414-21. PMID:15273289 doi:10.1073/pnas.0404211101

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