Serotonin Transporter: Difference between revisions
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==Introduction== | ==Introduction== | ||
[[Serotonin Transporter]]'''s''' ('''SERTs''') are integral membrane proteins that transport serotonin from synaptic spaces into presynaptic neurons. Serotonin is an important neurotransmitter which impacts a mammal’s perception of resource availability, regulates mood, and some cognitive functions like memory and learning. It is also converted into melatonin by [[Serotonin N-acetyltransferase]] to regulate sleep cycles. SERTs function by reuptaking serotonin in the synaptic cleft, effectively terminating the function of serotonin and halting neuronal transmission. Serotonin reuptake is a critical process to prevent overstimulation of nerves.<ref>PMID:10405096</ref> Inappropriately low levels of serotonin, either due to reduced production or overly active SERTs, can cause a number of psychiatric disorders. | [[Serotonin Transporter]]'''s''' ('''SERTs''') are integral membrane proteins that transport serotonin from synaptic spaces into presynaptic neurons. Serotonin is an important neurotransmitter which impacts a mammal’s perception of resource availability, regulates mood, and some cognitive functions like memory and learning. It is also converted into melatonin by [[Serotonin N-acetyltransferase]] to regulate sleep cycles. SERTs function by reuptaking serotonin in the synaptic cleft, effectively terminating the function of serotonin and halting neuronal transmission. Serotonin reuptake is a critical process to prevent overstimulation of nerves.<ref>PMID:10405096</ref> Inappropriately low levels of serotonin, either due to reduced production or overly active SERTs, can cause a number of psychiatric disorders. | ||
*'''TS2 SERT''' is a SERT thermostable double mutant I291A, T439S<ref>PMID:26695939</ref>. | |||
*'''TS3 SERT''' is a SERT thermostable triple mutant Y110A, I291A, T439S. | |||
==SERTs Involvement in OCD and Autism== | ==SERTs Involvement in OCD and Autism== | ||