3rgv: Difference between revisions

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-[[Image:3rgv.jpg|left|200px]]
-<!--
+==A single TCR bound to MHCI and MHC II reveals switchable TCR conformers==
-The line below this paragraph, containing "STRUCTURE_3rgv", creates the "Structure Box" on the page.
+<StructureSection load='3rgv' size='340' side='right'caption='[[3rgv]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3rgv]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RGV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3RGV FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3rgv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3rgv OCA], [https://pdbe.org/3rgv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3rgv RCSB], [https://www.ebi.ac.uk/pdbsum/3rgv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3rgv ProSAT]</span></td></tr>
-{{STRUCTURE_3rgv|  PDB=3rgv  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/HA1B_MOUSE HA1B_MOUSE] Involved in the presentation of foreign antigens to the immune system.
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Major histocompatibility complex class I (MHCI) and MHCII proteins differ in structure and sequence. To understand how T cell receptors (TCRs) can use the same set of variable regions to bind both proteins, we have presented a comparison of a single TCR bound to both MHCI and MHCII ligands. The TCR adopts similar orientations on both ligands with TCR amino acids thought to be evolutionarily conserved for MHC interaction occupying similar positions on the MHCI and MHCII helices. However, the TCR antigen-binding loops use different conformations when interacting with each ligand. Most importantly, we observed alternate TCR core conformations. When bound to MHCI, but not MHCII, Valpha disengages from the Jalpha beta strand, switching Valpha's position relative to Vbeta. In several other structures, either Valpha or Vbeta undergoes this same modification. Thus, both TCR V-domains can switch among alternate conformations, perhaps extending their ability to react with different MHC-peptide ligands.
-===A single TCR bound to MHCI and MHC II reveals switchable TCR conformers===
+A Single T Cell Receptor Bound to Major Histocompatibility Complex Class I and Class II Glycoproteins Reveals Switchable TCR Conformers.,Yin L, Huseby E, Scott-Browne J, Rubtsova K, Pinilla C, Crawford F, Marrack P, Dai S, Kappler JW Immunity. 2011 Jun 15. PMID:21683626<ref>PMID:21683626</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 3rgv" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_21683626}}, adds the Publication Abstract to the page
+*[[Beta-2 microglobulin 3D structures|Beta-2 microglobulin 3D structures]]
-(as it appears on PubMed at http://www.pubmed.gov), where 21683626 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_21683626}}
+__TOC__
+</StructureSection>
-==About this Structure==
+[[Category: Large Structures]]
-[[3rgv]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3RGV OCA].
-==Reference==
-<ref group="xtra">PMID:021683626</ref><references group="xtra"/>
 [[Category: Mus musculus]]
-[[Category: Crawford, F.]]
+[[Category: Crawford F]]
-[[Category: Dai, S.]]
+[[Category: Dai S]]
-[[Category: Huseby, E.]]
+[[Category: Huseby E]]
-[[Category: Kappler, J W.]]
+[[Category: Kappler JW]]
-[[Category: Marrack, P.]]
+[[Category: Marrack P]]
-[[Category: Pinilla, C.]]
+[[Category: Pinilla C]]
-[[Category: Rubtsova, K.]]
+[[Category: Rubtsova K]]
-[[Category: Scott-Browne, J.]]
+[[Category: Scott-Browne J]]
-[[Category: Yin, L.]]
+[[Category: Yin L]]
-[[Category: Immune system]]
-[[Category: Mhc]]
-[[Category: Mhc class i]]
-[[Category: Tcr]]