Crystallin: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Jaime Prilusky

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-{{STRUCTURE_2g98|  PDB=2g98  | SIZE=300| SCENE=Crystalline/C/1 |right|CAPTION=human γ-D-crystalline, [[2g98]] }}
+<StructureSection load='2g98' size='400' side='right' scene='Crystalline/C/1' caption='human γ-D-crystallin,  [[2g98]]'>
 == Function ==
-'''Crystalline''' is found in the lens of the eye accounting for the transparency and probably increasing the refractive index of it.  α-, β-, γ-, δ-crystalline are named according to the order they are eluted by gel filtration. δ-crystalline is found in avian and reptilian lenses.<ref>PMID:12729747</ref>
+'''Crystallin''' is found in the lens of the eye accounting for the transparency and probably increasing the refractive index of it.  '''α-, β-, γ-, δ-crystallin''' are named according to the order they are eluted by gel filtration.
+*'''Alpha crystallin''' has chaperone-like properties like the ability to prevent precipitation of denatured proteins<ref>PMID:15575808</ref>.  See [[Alpha crystallin]].
+*'''Gamma crystallin''' is found mainly in the nuclear region of the lens<ref>PMID:26116913</ref>.
+*.''' δ-crystallin''' is found in avian and reptilian lenses and missing from fish, amphibia and mammals lenses<ref>PMID:6369110</ref>.
+== Disease ==
+Mutations in α-A-crystallin and α-B-crystallin can cause myopathy<ref>PMID:12565801</ref>.  Several human cataracts have been linked to mutations in γ-D-crystallin<ref>PMID:11371638</ref>.
-== 3D Structures of Crystalline ==
+== 3D Structures of Crystallin ==
+[[Crystallin 3D structures]]
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
+</StructureSection>
-[[2g98]] - hγ-D-crystalline – human<br />
-[[1h4a]] - hγ-D-crystalline (mutant)<br />
-[[1elp]] - γ-D-crystalline – bovine<br />
-[[1auw]] - δ-2-crystalline (mutant) - duck
 == References ==