MAP kinase phosphatase: Difference between revisions
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== Function == | == Function == | ||
'''MAP kinase phosphatase''' (MKP) or '''Dual specificity phosphatase''' (DUSP) are phosphatases which reverse the activation of MAP kinases by dephosphorylating tyrosine or threonine residues<ref>PMID:18922965</ref>.<br /> | '''MAP kinase phosphatase''' (MKP) or '''Dual specificity phosphatase''' (DUSP) are phosphatases which reverse the activation of MAP kinases by dephosphorylating tyrosine or threonine residues<ref>PMID:18922965</ref>.<br /> | ||
*MKP-4 and MKP-5 | *'''MKP-2''' is essential in protection against intracellular infection<ref>PMID:21085614</ref>.<br /> | ||
*MKP-6, MKP-7 | *'''MKP-3''' is localized in the nucleus and dephosphorylates phosphoTyr in p38a<ref>PMID:21454500</ref>. | ||
*'''MKP-4''' is localized in the nucleus and cytosole<br /> | |||
*'''MKP-5''' is localized in the nucleus and cytosole and is involved in pressure overload-induced cardiac fibrosis<ref>PMID:34992607</ref>. | |||
*'''MKP-6, MKP-7''' are localized in the nucleus<br /> | |||
== Relevance == | == Relevance == | ||
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[[3lj8]] – hMKP-4<br /> | [[3lj8]] – hMKP-4<br /> | ||
[[4jmk]] – hDUSP-8 (mutant)<br /> | [[4jmk]] – hDUSP-8 (mutant)<br /> | ||
[[2ouc]], [[2oud]], [[1zzw]] - hMKP-5 or DUSP-10<br /> | [[2ouc]], [[2oud]], [[1zzw]], [[7y4c]] - hMKP-5 or DUSP-10<br /> | ||
[[7y4b]], [[7y4d]], [[7y4e]] – hMKP-5 (mutant)<br /> | |||
[[6mc1]], [[7u4o]], [[7u4r]], [[7umu]], [[7umv]], [[7un0]], [[7un4]] – hMKP-5 + inhibitor<br /> | |||
[[3tg1]] – hMKP-5 + MAP kinase 14<br /> | [[3tg1]] – hMKP-5 + MAP kinase 14<br /> | ||
[[4jmj]] – hDUSP-11 catalytic domain (mutant)<br /> | [[4jmj]] – hDUSP-11 catalytic domain (mutant)<br /> | ||