MAP kinase phosphatase: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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-[[Image:1hzm.png|left|200px|thumb|Crystal Structure of MAP kinase phosphatase [[1hzm]]]]
+<StructureSection load='1hzm' size='350' side='right' scene='' caption='MAP kinase phosphatase 3 (PDB code [[1hzm]])'>
-{{STRUCTURE_1hzm|  PDB=1hzm  | SIZE=400| SCENE=MAP_kinase_phosphatase/Cv/1 |right|CAPTION=MAP kinase phosphatase 3 [[1hzm]] }}
-{{TOC limit|limit=2}}
+== Function ==
+'''MAP kinase phosphatase''' (MKP) or '''Dual specificity phosphatase''' (DUSP) are phosphatases which reverse the activation of MAP kinases by dephosphorylating tyrosine or threonine residues<ref>PMID:18922965</ref>.<br />
-'''MAP kinase phosphatase''' (MKP) or '''Dual specificity phosphatase''' (DUSP) are phosphatases which reverse the activation of MAP kinases by dephosphorylating tyrosine or threonine residues.
+*'''MKP-2''' is essential in protection against intracellular infection<ref>PMID:21085614</ref>.<br />
+*'''MKP-3''' is localized in the nucleus and dephosphorylates phosphoTyr in p38a<ref>PMID:21454500</ref>.
+*'''MKP-4''' is localized in the nucleus and cytosole<br />
+*'''MKP-5''' is localized in the nucleus and cytosole and is involved in pressure overload-induced cardiac fibrosis<ref>PMID:34992607</ref>.
+*'''MKP-6, MKP-7''' are localized in the nucleus<br />
+== Relevance ==
+DUSP is implicated in the initiation and development of cancer<ref>PMID:18330678</ref>.
+</StructureSection>
 == 3D Structures of MAP kinase phosphatase ==
+Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 [[3ezz]] – hMKP-2 (mutant) or DUSP-HVH2  - human<br />
-[[2fys]] - hMKP-3 peptide or DUSP-5 +rMAP kinase – rat<br />
+[[2hcm]] – mDUSP<br />
+[[1m3g]] – hMKP-PAC-1 catalytic domain (mutant) - NMR<br />
+[[2g6z]] – hMKP-3<br />
 [[1hzm]] - hMKP-3 or DUSP-5<br />
 [[1mkp]] - hMKP-3 or DUSP-5 (mutant)<br />
 [[3lj8]] – hMKP-4<br />
-[[2ouc]], [[2oud]], [[1zzw]] - hMKP-5 or DUSP-10<br />
+[[4jmk]] – hDUSP-8 (mutant)<br />
+[[2ouc]], [[2oud]], [[1zzw]], [[7y4c]] - hMKP-5 or DUSP-10<br />
+[[7y4b]], [[7y4d]], [[7y4e]] – hMKP-5 (mutant)<br />
+[[6mc1]], [[7u4o]], [[7u4r]], [[7umu]], [[7umv]], [[7un0]], [[7un4]] – hMKP-5 + inhibitor<br />
+[[3tg1]] – hMKP-5 + MAP kinase 14<br />
+[[4jmj]] – hDUSP-11 catalytic domain (mutant)<br />
 [[2wgp]] – hMKP-6 or DUSP-14<br />
-[[2vsw]] - hMKP-7 or DUSP-16<br />
+[[1yz4]] – hDUSP-15 catalytic domain (mutant)<br />
-[[1j4x]] – hDUSP-3 (mutant)+peptide<br />
+[[2vsw]], [[3tg3]] - hMKP-7 or DUSP-16<br />
-[[2g6z]] – hDUSP-5<br />
+[[4yr8]] – hMKP-7 + MAPK8<br />
-[[2rf6]], [[2q05]] – DUSP – ''Vaccinia virus''
+[[4d3p]], [[4d3q]], [[4d3r]] – hDUSP-19 (mutant)<br />
+[[4woh]] – hDUSP-22 (mutant) + nitrophenolphosphate<br />
+[[2img]] – hDUSP-23 + malate <br />
+[[5gtj]], [[4b04]], [[4hrf]] – hDUSP-26 catalytic domain (mutant)<br />
+== References ==
+<references/>
 [[Category:Topic Page]]