Flavocytochrome: Difference between revisions

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*  '''Fcc''' catalyzes the conversion of H2S and ferricytochrome c to S and ferrocytochrome c.<br />
* '''Flavocytochrome c''' or '''flavocytochrome c sulphide dehydrogenase''' or '''Fcc''' catalyzes the conversion of H2S and ferricytochrome c to S and ferrocytochrome c.<br />
*  '''Fcc3''' has fumarate reductase activity<ref>PMID:12093271</ref>   
*  '''Fcc3''' has fumarate reductase activity<ref>PMID:12093271</ref>   
* '''Flavocytochrome b2''' is a L-lactate/cytochrome c oxidoreductase<ref>PMID:15260495</ref>
* '''Flavocytochrome b558''' is the catalytic component of the phagocyte NADPH oxidase


<scene name='44/442751/Cv/10'>Structure of heme-containing flavocytochrome c3 complex with FAD and fumaric acid</scene> (PDB code [[2b7r]]<ref>PMID:16699170</ref>).
<scene name='44/442751/Cv/10'>Structure of heme-containing flavocytochrome c3 complex with FAD and fumaric acid</scene> (PDB code [[2b7r]]<ref>PMID:16699170</ref>).

Latest revision as of 09:17, 25 June 2024


  • Flavocytochrome c or flavocytochrome c sulphide dehydrogenase or Fcc catalyzes the conversion of H2S and ferricytochrome c to S and ferrocytochrome c.
  • Fcc3 has fumarate reductase activity[1]
  • Flavocytochrome b2 is a L-lactate/cytochrome c oxidoreductase[2]
  • Flavocytochrome b558 is the catalytic component of the phagocyte NADPH oxidase

(PDB code 2b7r[3]).

  • . Water molecules are shown as red spheres.
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Interestedly, that all 4 heme groups are in heme-containing flavocytochrome c3 (PDB code 2b7r).

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3D Structures of flavocytochrome

Flavocytochrome 3D structures


Structure of heme-containing flavocytochrome c3 complex with FAD and fumaric acid (PDB code 2b7r).

Drag the structure with the mouse to rotate

ReferencesReferences

  1. ↑ Pankhurst KL, Mowat CG, Miles CS, Leys D, Walkinshaw MD, Reid GA, Chapman SK. Role of His505 in the soluble fumarate reductase from Shewanella frigidimarina. Biochemistry. 2002 Jul 9;41(27):8551-6. PMID:12093271
  2. ↑ Mowat CG, Wehenkel A, Green AJ, Walkinshaw MD, Reid GA, Chapman SK. Altered substrate specificity in flavocytochrome b2: structural insights into the mechanism of L-lactate dehydrogenation. Biochemistry. 2004 Jul 27;43(29):9519-26. PMID:15260495 doi:http://dx.doi.org/10.1021/bi049263m
  3. ↑ Pankhurst KL, Mowat CG, Rothery EL, Hudson JM, Jones AK, Miles CS, Walkinshaw MD, Armstrong FA, Reid GA, Chapman SK. A proton delivery pathway in the soluble fumarate reductase from Shewanella frigidimarina. J Biol Chem. 2006 Jul 21;281(29):20589-97. Epub 2006 May 12. PMID:16699170 doi:http://dx.doi.org/10.1074/jbc.M603077200

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