2lag: Difference between revisions

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 ==Structure of the 44 kDa complex of interferon-alpha2 with the extracellular part of IFNAR2 obtained by 2D-double difference NOESY==
-<StructureSection load='2lag' size='340' side='right' caption='[[2lag]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
+<StructureSection load='2lag' size='340' side='right'caption='[[2lag]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2lag]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LAG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2LAG FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2lag]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LAG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LAG FirstGlance]. <br>
-</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1kz1|1kz1]]</td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 10 models</td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IFNAR2, IFNABR, IFNARB ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), IFNA2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lag FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lag OCA], [https://pdbe.org/2lag PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lag RCSB], [https://www.ebi.ac.uk/pdbsum/2lag PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lag ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2lag FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lag OCA], [http://pdbe.org/2lag PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2lag RCSB], [http://www.ebi.ac.uk/pdbsum/2lag PDBsum]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/INAR2_HUMAN INAR2_HUMAN]] Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 is a potent inhibitor of type I IFN receptor activity.<ref>PMID:8181059</ref> <ref>PMID:7665574</ref> <ref>PMID:7759950</ref> <ref>PMID:11682488</ref> <ref>PMID:12105218</ref>  [[http://www.uniprot.org/uniprot/IFNA2_HUMAN IFNA2_HUMAN]] Produced by macrophages, IFN-alpha have antiviral activities.
+[https://www.uniprot.org/uniprot/INAR2_HUMAN INAR2_HUMAN] Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN-mediated STAT1, STAT2 and STAT3 activation. Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1. Isoform 3 is a potent inhibitor of type I IFN receptor activity.<ref>PMID:8181059</ref> <ref>PMID:7665574</ref> <ref>PMID:7759950</ref> <ref>PMID:11682488</ref> <ref>PMID:12105218</ref>
 <div style="background-color:#fffaf0;">
 == Publication Abstract from PubMed ==
@@ Line 20: / Line 20: @@
 ==See Also==
-*[[Interferon|Interferon]]
+*[[Interferon 3D structures|Interferon 3D structures]]
-*[[Interferon receptor|Interferon receptor]]
+*[[Interferon receptor 3D structures|Interferon receptor 3D structures]]
 *[[Multiple sclerosis|Multiple sclerosis]]
 == References ==
@@ Line 27: / Line 27: @@
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
-[[Category: Akabayov, S R]]
+[[Category: Large Structures]]
-[[Category: Anglister, J]]
+[[Category: Akabayov SR]]
-[[Category: Nudelman, I]]
+[[Category: Anglister J]]
-[[Category: Scherf, T]]
+[[Category: Nudelman I]]
-[[Category: Immune system]]
+[[Category: Scherf T]]
-[[Category: Interferon]]
-[[Category: Receptor]]