3qw0: Difference between revisions

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[[Image:3qw0.jpg|left|200px]]


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==Crystal structure of the Zn-RIDC1 complex stabilized by BMB crosslinks==
The line below this paragraph, containing "STRUCTURE_3qw0", creates the "Structure Box" on the page.
<StructureSection load='3qw0' size='340' side='right'caption='[[3qw0]], [[Resolution|resolution]] 1.84&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)  
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3qw0]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QW0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QW0 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.84&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BTB:2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>BTB</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene>, <scene name='pdbligand=ME9:1,1-BUTANE-1,4-DIYLBIS(1H-PYRROLE-2,5-DIONE)'>ME9</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
{{STRUCTURE_3qw0|  PDB=3qw0  |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qw0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qw0 OCA], [https://pdbe.org/3qw0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qw0 RCSB], [https://www.ebi.ac.uk/pdbsum/3qw0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qw0 ProSAT]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Here, we report that the approach of metal-templated ligand synthesis can be applied to construct a dimeric protein assembly ((BMOE)RIDC1(2)), which is stabilized by noncovalent interactions and flexible covalent cross-linkers around the Zn templates. Despite its flexibility, (BMOE)RIDC1(2) selectively binds Zn(II) over other divalent metals and undergoes dimerization upon metal binding. Such simultaneous fulfillment of plasticity and selectivity is a hallmark of cellular signaling events that involve ligand/metal-induced protein dimerization.


===Crystal structure of the Zn-RIDC1 complex stabilized by BMB crosslinks===
Templated Construction of a Zn-Selective Protein Dimerization Motif.,Salgado EN, Brodin JD, To MM, Tezcan FA Inorg Chem. 2011 Jun 7. PMID:21648390<ref>PMID:21648390</ref>


From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3qw0" style="background-color:#fffaf0;"></div>


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==See Also==
The line below this paragraph, {{ABSTRACT_PUBMED_21648390}}, adds the Publication Abstract to the page
*[[Cytochrome C 3D structures|Cytochrome C 3D structures]]
(as it appears on PubMed at http://www.pubmed.gov), where 21648390 is the PubMed ID number.
== References ==
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<references/>
{{ABSTRACT_PUBMED_21648390}}
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</StructureSection>
==About this Structure==
[[3qw0]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QW0 OCA].
 
==Reference==
<ref group="xtra">PMID:021648390</ref><references group="xtra"/>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Salgado, E N.]]
[[Category: Large Structures]]
[[Category: Tezcan, F A.]]
[[Category: Salgado EN]]
[[Category: Four-helix bundle]]
[[Category: Tezcan FA]]
[[Category: Oxidoreductase]]

Latest revision as of 09:42, 27 November 2024

Crystal structure of the Zn-RIDC1 complex stabilized by BMB crosslinksCrystal structure of the Zn-RIDC1 complex stabilized by BMB crosslinks

Structural highlights

3qw0 is a 4 chain structure with sequence from Escherichia coli. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.84Å
Ligands:, , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Publication Abstract from PubMed

Here, we report that the approach of metal-templated ligand synthesis can be applied to construct a dimeric protein assembly ((BMOE)RIDC1(2)), which is stabilized by noncovalent interactions and flexible covalent cross-linkers around the Zn templates. Despite its flexibility, (BMOE)RIDC1(2) selectively binds Zn(II) over other divalent metals and undergoes dimerization upon metal binding. Such simultaneous fulfillment of plasticity and selectivity is a hallmark of cellular signaling events that involve ligand/metal-induced protein dimerization.

Templated Construction of a Zn-Selective Protein Dimerization Motif.,Salgado EN, Brodin JD, To MM, Tezcan FA Inorg Chem. 2011 Jun 7. PMID:21648390[1]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

See Also

References

  1. ↑ Salgado EN, Brodin JD, To MM, Tezcan FA. Templated Construction of a Zn-Selective Protein Dimerization Motif. Inorg Chem. 2011 Jun 7. PMID:21648390 doi:10.1021/ic200746m

3qw0, resolution 1.84Å

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