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== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/A0A0H3LJQ6_BORBR A0A0H3LJQ6_BORBR] | [https://www.uniprot.org/uniprot/A0A0H3LJQ6_BORBR A0A0H3LJQ6_BORBR] | ||
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== Publication Abstract from PubMed == | |||
We report a 2.0 A structure of the CAE31940 protein, a proteobacterial NMT1/THI5-like domain-containing protein. We also discuss the primary and tertiary structure similarity with its homologs. The highly conserved FGGXMP motif was identified in CAE31940, which corresponds to the GCCCX motif located in the vicinity of the active center characteristic for THi5-like proteins found in yeast. This suggests that the FGGXMP motif may be a unique hallmark of proteobacterial NMT1/THI5-like proteins. | |||
The crystal structure of pyrimidine/thiamin biosynthesis precursor-like domain-containing protein CAE31940 from proteobacterium Bordetella bronchiseptica RB50, and evolutionary insight into the NMT1/THI5 family.,Bajor J, Tkaczuk KL, Chruszcz M, Chapman H, Kagan O, Savchenko A, Minor W J Struct Funct Genomics. 2014 Jun;15(2):73-81. doi: 10.1007/s10969-014-9180-3. , Epub 2014 Jun 8. PMID:24908050<ref>PMID:24908050</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
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<div class="pdbe-citations 3qsl" style="background-color:#fffaf0;"></div> | |||
== References == | |||
<references/> | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Latest revision as of 09:42, 27 November 2024
Structure of CAE31940 from Bordetella bronchiseptica RB50Structure of CAE31940 from Bordetella bronchiseptica RB50
Structural highlights
FunctionPublication Abstract from PubMedWe report a 2.0 A structure of the CAE31940 protein, a proteobacterial NMT1/THI5-like domain-containing protein. We also discuss the primary and tertiary structure similarity with its homologs. The highly conserved FGGXMP motif was identified in CAE31940, which corresponds to the GCCCX motif located in the vicinity of the active center characteristic for THi5-like proteins found in yeast. This suggests that the FGGXMP motif may be a unique hallmark of proteobacterial NMT1/THI5-like proteins. The crystal structure of pyrimidine/thiamin biosynthesis precursor-like domain-containing protein CAE31940 from proteobacterium Bordetella bronchiseptica RB50, and evolutionary insight into the NMT1/THI5 family.,Bajor J, Tkaczuk KL, Chruszcz M, Chapman H, Kagan O, Savchenko A, Minor W J Struct Funct Genomics. 2014 Jun;15(2):73-81. doi: 10.1007/s10969-014-9180-3. , Epub 2014 Jun 8. PMID:24908050[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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