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==Structure of CAE31940 from Bordetella bronchiseptica RB50==
==Structure of CAE31940 from Bordetella bronchiseptica RB50==
<StructureSection load='3qsl' size='340' side='right' caption='[[3qsl]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='3qsl' size='340' side='right'caption='[[3qsl]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3qsl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/"alcaligenes_bronchicanis"_(ferry_1911)_haupt_1935 "alcaligenes bronchicanis" (ferry 1911) haupt 1935]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QSL OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3QSL FirstGlance]. <br>
<table><tr><td colspan='2'>[[3qsl]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Bordetella_bronchiseptica Bordetella bronchiseptica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3QSL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3QSL FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">BB1442 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=518 "Alcaligenes bronchicanis" (Ferry 1911) Haupt 1935])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3qsl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qsl OCA], [https://pdbe.org/3qsl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3qsl RCSB], [https://www.ebi.ac.uk/pdbsum/3qsl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3qsl ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3qsl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3qsl OCA], [http://pdbe.org/3qsl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3qsl RCSB], [http://www.ebi.ac.uk/pdbsum/3qsl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3qsl ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/A0A0H3LJQ6_BORBR A0A0H3LJQ6_BORBR]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
We report a 2.0 A structure of the CAE31940 protein, a proteobacterial NMT1/THI5-like domain-containing protein. We also discuss the primary and tertiary structure similarity with its homologs. The highly conserved FGGXMP motif was identified in CAE31940, which corresponds to the GCCCX motif located in the vicinity of the active center characteristic for THi5-like proteins found in yeast. This suggests that the FGGXMP motif may be a unique hallmark of proteobacterial NMT1/THI5-like proteins.
The crystal structure of pyrimidine/thiamin biosynthesis precursor-like domain-containing protein CAE31940 from proteobacterium Bordetella bronchiseptica RB50, and evolutionary insight into the NMT1/THI5 family.,Bajor J, Tkaczuk KL, Chruszcz M, Chapman H, Kagan O, Savchenko A, Minor W J Struct Funct Genomics. 2014 Jun;15(2):73-81. doi: 10.1007/s10969-014-9180-3. , Epub 2014 Jun 8. PMID:24908050<ref>PMID:24908050</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 3qsl" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bajor, J]]
[[Category: Bordetella bronchiseptica]]
[[Category: Chruszcz, M]]
[[Category: Large Structures]]
[[Category: Joachimiak, A]]
[[Category: Bajor J]]
[[Category: Kagan, O]]
[[Category: Chruszcz M]]
[[Category: Structural genomic]]
[[Category: Joachimiak A]]
[[Category: Minor, W]]
[[Category: Kagan O]]
[[Category: Savchenko, A]]
[[Category: Minor W]]
[[Category: Mcsg]]
[[Category: Savchenko A]]
[[Category: Psi-biology]]
[[Category: Unknown]]
[[Category: Unknown function]]

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