Spectrin: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Alexander Berchansky, Michal Harel

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 <StructureSection load='3lbx' size='340' side='right' caption='Human spectrin α (grey) and β1 chain (green) [[3lbx]]' scene=''>
 == Function ==
 [[Spectrin]] forms scaffolding in plasma membranes and cytoskeletal structure.  It interacts with actin at either end of its tetramer<ref>PMID:17060500</ref>.  The SPT dimer is formed by association of α1 and β1 monomers.  In invertebrates there are SPT α, β and βH.  In vertebrates there are SPT α1 (SPTA1), α2 (SPTA2) and β1 (SPTB1) to β5.  SPT contains an SRC Homology 3 domain (SH3), a Pleckstrin Homology (PH) domain and a Calponin Homology (CH) domain.
+*'''Spectrin α2''' is expressed highly in heart muscle cells<ref>PMID:15360127</ref>.
+*'''Spectrin β2''' is associated with GABA receptor at dendritic synapses<ref>PMID:36604600</ref>.
+*'''Spectrin β4''' is associated with GABA receptor at axon initial segment synapses.
+*'''Spectrin R16''' is spectrin α first repeat domain<ref>PMID:10481916</ref>.
 == Disease ==
 Mutations in SPT α are found in patients with hereditary elliptocytosis<ref>PMID:2346784</ref>. SPT β deficiency is found in hereditary spherocytosis<ref>PMID:9714702</ref>.
+== 3D Structures of Spectrin ==
+[[Spectrin 3D structures]]
 </StructureSection>
-== 3D Structures of Spectrin ==
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-{{#tree:id=OrganizedByTopic|openlevels=0|
-* Spectrin α1
-**[[3lbx]] – hSPTA1+hSPTB1 – human<br />
-**[[3i9q]], [[2rot]], [[2oaw]], [[2nuz]], [[1u06]] - cSPTA1 SH3 domain – chicken<br />
-**[[2jm8]], [[2jm9]], [[2cdt]], [[2f2v]], [[2f2w]], [[2f2x]] - cSPTA1 SH3 domain (mutant)<br />
-**[[2jma]], [[2jmc]] - cSPTA1 SH3 domain (mutant)+P41 peptide<br />
-**[[2rmo]], [[1neg]], [[1m8m]] - cSPTA1 SH3 domain – NMR
-* Spectrin α2
-**[[3f31]] – hSPTA2 tetramerization domain<br />
-**[[1qkw]] – cSPTA2 SH3 domain (mutant)<br />
-**[[2fot]] - SPTA2+calmodulin – bovine<br />
-**[[3fb2]] – hSPTA2 repeats 15-16<br />
-**[[3thk]] - SPTA2 SH3 domain + polypeptide - rat
-* Spectrin α
-**[[1uue]], [[1e7o]], [[1g2b]], [[1aey]], [[1tuc]], [[1tud]] - cSPTA SH3 domain (mutant) – NMR<br />
-**[[2lj3]] - cSPTA SH3 domain – NMR<br />
-**[[1e6g]], [[1e6h]], [[1hd3]], [[1qkx]], [[1pwt]], [[1bk2]], [[1shg]] - cSPTA SH3 domain (mutant)<br />
-**[[1u4q]] – cSPTA repeats 15-17 <br />
-**[[1u5p]] - cSPTA repeats 15-16<br />
-**[[1cun]] - cSPTA repeats 16-17<br />
-**[[1aj3]] - cSPTA repeat 16 - NMR<br />
-**[[1owa]] - hSPTA tetramerization domain – NMR<br />
-**[[1h8k]], [[3ngp]], [[3m0p]], [[3m0q]], [[3m0r]], [[3m0s]], [[3m0t]], [[3m0u]] – cSPTA SH3 domain (mutant)<br />
-**[[2kr3]], [[4f17]], [[4f16]] - cSPTA SH3 domain<br />
-* Spectrin β1
-**[[3bkt]], [[3kbu]] - hSPTB1+ankyrin<br />
-**[[3f57]], [[3edu]] - hSPTB1 ankyrin binding domain<br />
-**[[1s35]] – hSPTB1 repeats 8-9
-* Spectrin β2
-**[[3edv]] – hSPTB2 repeats 14-16
-* Spectrin β3
-**[[1wyq]] – hSPTB3 CH domain – NMR<br />
-**[[1wjm]] – hSPTB3 – NMR
-* Spectrin β
-**[[1bkr]], [[1aa2]] – hSPTB CH domain<br />
-**[[1mph]] – SPTB Pleckstrin Homology domain – NMR<br />
-**[[1dro]] - mSPTB PH domain – NMR – mouse<br />
-**[[1btn]] – mSPTB+inositol phosphate<br />
-**[[2spc]] – SPT fragment - ''Drosophila melanogaster''
-}}
 == References ==
 <references/>
 [[Category:Topic Page]]