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| [[Image:3lbx.png|left|200px|thumb|Crystal Structure of Spectrin [[3lbx]]]]
| | <StructureSection load='3lbx' size='340' side='right' caption='Human spectrin α (grey) and β1 chain (green) [[3lbx]]' scene=''> |
| {{STRUCTURE_3lbx| PDB=3lbx | SIZE=300| SCENE= |right|CAPTION=Spectrin α (grey) and β chain (green) [[3lbx]] }}
| | == Function == |
| | [[Spectrin]] forms scaffolding in plasma membranes and cytoskeletal structure. It interacts with actin at either end of its tetramer<ref>PMID:17060500</ref>. The SPT dimer is formed by association of α1 and β1 monomers. In invertebrates there are SPT α, β and βH. In vertebrates there are SPT α1 (SPTA1), α2 (SPTA2) and β1 (SPTB1) to β5. SPT contains an SRC Homology 3 domain (SH3), a Pleckstrin Homology (PH) domain and a Calponin Homology (CH) domain. |
| | *'''Spectrin α2''' is expressed highly in heart muscle cells<ref>PMID:15360127</ref>. |
| | *'''Spectrin β2''' is associated with GABA receptor at dendritic synapses<ref>PMID:36604600</ref>. |
| | *'''Spectrin β4''' is associated with GABA receptor at axon initial segment synapses. |
| | *'''Spectrin R16''' is spectrin α first repeat domain<ref>PMID:10481916</ref>. |
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| [[Spectrin]] forms scaffolding in plasma membranes and cytoskeletal structure. It interacts with actin at either end of its tetramer. The SPT dimer is formed by association of alpha1 and beta1 monomers. In invertebrates there are SPT alpha, beta and betaH. In vertebrates there are SPT alpha1 (SPTA1), alpha2 (SPTA2) and beta1 (SPTB1) to beta5. SPT contains an SRC Homology 3 domain (SH3), a Pleckstrin Homology (PH) domain and a Calponin Homology (CH) domain. The images at the left and at the right correspond to one representative Spectrin, ''i.e.'' the crystal structure of human Spectrin ([[3lbx]]).
| | == Disease == |
| | | Mutations in SPT α are found in patients with hereditary elliptocytosis<ref>PMID:2346784</ref>. SPT β deficiency is found in hereditary spherocytosis<ref>PMID:9714702</ref>. |
| {{TOC limit|limit=2}}
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| == 3D Structures of Spectrin == | | == 3D Structures of Spectrin == |
| | [[Spectrin 3D structures]] |
| | </StructureSection> |
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| ''Update July 2012''
| | == References == |
| | | <references/> |
| === SPTA1 ===
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| [[3lbx]] – hSPTA1+hSPTB1 – human<br />
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| [[3i9q]], [[2rot]], [[2pqh]], [[2oaw]], [[2nuz]], [[1u06]] - cSPTA1 SH3 domain – chicken<br />
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| [[2jm8]], [[2jm9]], [[2cdt]], [[2f2v]], [[2f2w]], [[2f2x]] - cSPTA1 SH3 domain (mutant)<br />
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| [[2jma]], [[2jmc]] - cSPTA1 SH3 domain (mutant)+P41 peptide<br />
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| [[2rmo]], [[1neg]], [[1m8m]] - cSPTA1 SH3 domain – NMR
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| === SPTA2 ===
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| [[3f31]] – hSPTA2 tetramerization domain<br />
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| [[1qkw]] – cSPTA2 SH3 domain (mutant)<br />
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| [[2fot]] - SPTA2+calmodulin – bovine<br />
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| [[3fb2]] – hSPTA2 repeats 15-16<br />
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| [[3thk]] - SPTA2 SH3 domain + polypeptide - rat
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| === SPTA ===
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| [[1uue]], [[1e7o]], [[1g2b]], [[1aey]], [[1tuc]], [[1tud]] - cSPTA SH3 domain (mutant) – NMR<br />
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| [[1e6g]], [[1e6h]], [[1hd3]], [[1qkx]], [[1pwt]], [[1bk2]], [[1shg]] - cSPTA SH3 domain (mutant)<br />
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| [[1u4q]] – cSPTA repeats 15-17 <br />
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| [[1u5p]] - cSPTA repeats 15-16<br />
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| [[1cun]] - cSPTA repeats 16-17<br />
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| [[1aj3]] - cSPTA repeat 16 - NMR<br />
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| [[1owa]] - hSPTA tetramerization domain – NMR<br />
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| [[1h8k]], [[3ngp]], [[3m0p]], [[3m0q]], [[3m0r]], [[3m0s]], [[3m0t]], [[3m0u]] – cSPTA SH3 domain (mutant)<br />
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| [[2kr3]] - cSPTA SH3 domain<br />
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| === SPTB1 ===
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| [[3bkt]], [[3kbu]] - hSPTB1+ankyrin<br />
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| [[3f57]], [[3edu]] - hSPTB1 ankyrin binding domain<br />
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| [[1s35]] – hSPTB1 repeats 8-9
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| === SPTB2 ===
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| [[3edv]] – hSPTB2 repeats 14-16
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| === SPTB3 ===
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| [[1wyq]] – hSPTB3 CH domain – NMR<br />
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| [[1wjm]] – hSPTB3 – NMR
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| === SPTB ===
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| [[1bkr]], [[1aa2]] – hSPTB CH domain<br />
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| [[1mph]] – SPTB Pleckstrin Homology domain – NMR<br />
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| [[1dro]] - mSPTB PH domain – NMR – mouse<br />
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| [[1btn]] – mSPTB+inositol phosphate<br />
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| [[2spc]] – SPT fragment - Drosophila
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| [[Category:Topic Page]] | | [[Category:Topic Page]] |