Colicin: Difference between revisions
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Colicin peptides are plasmid-encoded. The peptide is released by the cell into the area surrounding it, and then parasitises proteins present in the host cell membrane to translocate across into the host cell. Many protein-protein interactions are involved in the cell entry, and the main system is involved in the grouping of colicins into two families: Group A colicins use the [[Tol]] system to enter the host cell, and Group B use the [[Ton]] system. Once inside the host cell, the cell killing follows 1st order kinetics - ie one molecule is theoretically sufficient to kill the cell<ref> PMID: 7577966 </ref>. | Colicin peptides are plasmid-encoded. The peptide is released by the cell into the area surrounding it, and then parasitises proteins present in the host cell membrane to translocate across into the host cell. Many protein-protein interactions are involved in the cell entry, and the main system is involved in the grouping of colicins into two families: Group A colicins use the [[Tol]] system to enter the host cell, and Group B use the [[Ton]] system. Once inside the host cell, the cell killing follows 1st order kinetics - ie one molecule is theoretically sufficient to kill the cell<ref> PMID: 7577966 </ref>. | ||
*'''Colicin-A''' see [[Colicin-A]] | *'''Colicin-A''' see [[Colicin-A]] | ||
*'''Colicin-B forms small, ion-permeable channels. It inhibits the transport of Pro and enhances the transport of methylglucoside<ref> PMID:2419320 </ref>.''' | *'''Colicin-B''' forms small, ion-permeable channels. It inhibits the transport of Pro and enhances the transport of methylglucoside<ref> PMID:2419320 </ref>. | ||
*'''Colicin-D''' cleaves the anticodon loop of tRNAArg<ref> PMID:15014439 </ref> | |||
*'''Colicin-E1''' binds to TolC and plug channels of Gram-negative bacteria<ref> PMID:35199644 </ref> | |||
*'''Colicin-E2''' and '''Colicin-E9''' bind to BtuB and cleaves the target DNA<ref> PMID:17416663 </ref>, <ref> PMID:15995205 </ref> | |||
*'''Colicin-E3''' cleaves the ribosome A site<ref> PMID:11741540 </ref> | |||
*'''Colicin-E5''' cleaves tRNA which contain the nucleotide queuosine<ref> PMID:16060658 </ref> | |||
*'''Colicin-E7''' binds to immunity protein 7<ref> PMID:10368275 </ref> | |||
*'''Colicin-Ia''' see [[Colicin-Ia]] | |||
*'''Colicin-M''' cleaves peptidoglycans by hydrolysing their phosphoester bonds<ref> PMID:23176510 </ref> | |||
The structure of all colicins, of which over 20 have been identified, follows a 3 domain design: | The structure of all colicins, of which over 20 have been identified, follows a 3 domain design: | ||
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*[[Translocation domain]]<br /> | *[[Translocation domain]]<br /> | ||
*[[H-N-H motif]]<br /> | *[[H-N-H motif]]<br /> | ||
*[[16s rRNase activity]]<br /> | *[[16s rRNase activity]]<br /> | ||
*[[Cloacin DF13]]. | *[[Cloacin DF13]]. | ||
*[[Colicin Immunity Protein]] | *[[Colicin Immunity Protein]] | ||