3p2r: Difference between revisions
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==Crystal structure of the fluoroacetyl-CoA-specific thioesterase FlK in complex with fluoroacetate== | ==Crystal structure of the fluoroacetyl-CoA-specific thioesterase FlK in complex with fluoroacetate== | ||
<StructureSection load='3p2r' size='340' side='right' caption='[[3p2r]], [[Resolution|resolution]] 2.46Å' scene=''> | <StructureSection load='3p2r' size='340' side='right'caption='[[3p2r]], [[Resolution|resolution]] 2.46Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3p2r]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[3p2r]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptomyces_cattleya Streptomyces cattleya]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3P2R OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3P2R FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.46Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAH:FLUOROACETIC+ACID'>FAH</scene></td></tr> | |||
<tr id=' | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3p2r FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3p2r OCA], [https://pdbe.org/3p2r PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3p2r RCSB], [https://www.ebi.ac.uk/pdbsum/3p2r PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3p2r ProSAT]</span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/FLK_STRCT FLK_STRCT] Hydrolyzes fluoroacetyl-CoA before it can react with citrate synthase, and thus confers fluoroacetate resistance. Can not use acetyl-CoA as substrate.<ref>PMID:16720268</ref> <ref>PMID:20836570</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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==See Also== | ==See Also== | ||
*[[Thioesterase|Thioesterase]] | *[[Thioesterase 3D structures|Thioesterase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Streptomyces cattleya | [[Category: Large Structures]] | ||
[[Category: Chang | [[Category: Streptomyces cattleya]] | ||
[[Category: Coyle | [[Category: Chang MCY]] | ||
[[Category: Doudna | [[Category: Coyle SM]] | ||
[[Category: Jinek | [[Category: Doudna JA]] | ||
[[Category: Weeks | [[Category: Jinek M]] | ||
[[Category: Weeks AM]] | |||