3ov0: Difference between revisions

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-[[Image:3ov0.png|left|200px]]
-<!--
+==Structure of dodecaheme cytochrome c GSU1996==
-The line below this paragraph, containing "STRUCTURE_3ov0", creates the "Structure Box" on the page.
+<StructureSection load='3ov0' size='340' side='right'caption='[[3ov0]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3ov0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Geobacter_sulfurreducens Geobacter sulfurreducens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OV0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OV0 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.2&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEC:HEME+C'>HEC</scene></td></tr>
-{{STRUCTURE_3ov0|  PDB=3ov0  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ov0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ov0 OCA], [https://pdbe.org/3ov0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ov0 RCSB], [https://www.ebi.ac.uk/pdbsum/3ov0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ov0 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q74BP5_GEOSL Q74BP5_GEOSL]
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Multiheme cytochromes c are important in electron transfer pathways in reduction of both soluble and insoluble Fe(III) by Geobacter sulfurreducens. We determined the crystal structure at 3.2A resolution of the first dodecaheme cytochrome c (GSU1996) along with its N-terminal and C-terminal hexaheme fragments at 2.6 and 2.15A resolution, respectively. The macroscopic reduction potentials of the full-length protein and its fragments were measured. The sequence of GSU1996 can be divided into four c(7)-type domains (A, B, C and D) with homology to triheme cytochromes c(7). In cytochromes c(7) all three hemes are bis-His coordinated, whereas in c(7)-type domains the last heme is His-Met coordinated. The full-length GSU1996 has a 12nm long crescent shaped structure with the 12 hemes arranged along a polypeptide to form a "nanowire" of hemes; it has a modular structure. Surprisingly, while the C-terminal half of the protein consists of two separate c(7)-type domains (C and D) connected by a small linker, the N-terminal half of the protein has two c(7)-type domains (A and B) that form one structural unit. This is also observed in the AB fragment. There is an unexpected interaction between the hemes at the interface of domains A and B, which form a heme-pair with nearly parallel stacking of their porphyrin rings. The hemes adjacent to each other throughout the protein are within van der Waals distance which enables efficient electron exchange between them. For the first time, the structural details of c(7)-type domains from one multiheme protein were compared.
-===Structure of dodecaheme cytochrome c GSU1996===
+Structure of a novel dodecaheme cytochrome c from Geobacter sulfurreducens reveals an extended 12nm protein with interacting hemes.,Pokkuluri PR, Londer YY, Duke NE, Pessanha M, Yang X, Orshonsky V, Orshonsky L, Erickson J, Zagyansky Y, Salgueiro CA, Schiffer M J Struct Biol. 2010 Dec 3. PMID:21130881<ref>PMID:21130881</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 3ov0" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_21130881}}, adds the Publication Abstract to the page
+*[[Cytochrome C 3D structures|Cytochrome C 3D structures]]
-(as it appears on PubMed at http://www.pubmed.gov), where 21130881 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_21130881}}
+__TOC__
+</StructureSection>
-==About this Structure==
-[[3ov0]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Geobacter_sulfurreducens Geobacter sulfurreducens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OV0 OCA].
-==Reference==
-<ref group="xtra">PMID:21130881</ref><references group="xtra"/>
 [[Category: Geobacter sulfurreducens]]
-[[Category: Pokkuluri, P R.]]
+[[Category: Large Structures]]
-[[Category: Schiffer, M.]]
+[[Category: Pokkuluri PR]]
+[[Category: Schiffer M]]