2l2g: Difference between revisions

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-[[Image:2l2g.jpg|left|200px]]
-<!--
+==Solution structure of Opossum Domain 11==
-The line below this paragraph, containing "STRUCTURE_2l2g", creates the "Structure Box" on the page.
+<StructureSection load='2l2g' size='340' side='right'caption='[[2l2g]]' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2l2g]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Monodelphis_domestica Monodelphis domestica]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L2G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L2G FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l2g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l2g OCA], [https://pdbe.org/2l2g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l2g RCSB], [https://www.ebi.ac.uk/pdbsum/2l2g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l2g ProSAT]</span></td></tr>
-{{STRUCTURE_2l2g|  PDB=2l2g  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/F6SWY2_MONDO F6SWY2_MONDO]
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Placental development and genomic imprinting coevolved with parental conflict over resource distribution to mammalian offspring. The imprinted genes IGF2 and IGF2R code for the growth promoter insulin-like growth factor 2 (IGF2) and its inhibitor, mannose 6-phosphate (M6P)/IGF2 receptor (IGF2R), respectively. M6P/IGF2R of birds and fish do not recognize IGF2. In monotremes, which lack imprinting, IGF2 specifically bound M6P/IGF2R via a hydrophobic CD loop. We show that the DNA coding the CD loop in monotremes functions as an exon splice enhancer (ESE) and that structural evolution of binding site loops (AB, HI, FG) improved therian IGF2 affinity. We propose that ESE evolution led to the fortuitous acquisition of IGF2 binding by M6P/IGF2R that drew IGF2R into parental conflict; subsequent imprinting may then have accelerated affinity maturation.
-===Solution structure of Opossum Domain 11===
+An exon splice enhancer primes IGF2:IGF2R binding site structure and function evolution.,Williams C, Hoppe HJ, Rezgui D, Strickland M, Forbes BE, Grutzner F, Frago S, Ellis RZ, Wattana-Amorn P, Prince SN, Zaccheo OJ, Nolan CM, Mungall AJ, Jones EY, Crump MP, Hassan AB Science. 2012 Nov 30;338(6111):1209-13. doi: 10.1126/science.1228633. PMID:23197533<ref>PMID:23197533</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 2l2g" style="background-color:#fffaf0;"></div>
-==About this Structure==
+==See Also==
-[[2l2g]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Monodelphis_domestica Monodelphis domestica]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L2G OCA].
+*[[Insulin-like growth factor receptor|Insulin-like growth factor receptor]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Monodelphis domestica]]
-[[Category: Bassim, A H.]]
+[[Category: Bassim AH]]
-[[Category: Crump, M P.]]
+[[Category: Crump MP]]
-[[Category: Ellis, R Z.]]
+[[Category: Ellis RZ]]
-[[Category: Forbes, B.]]
+[[Category: Forbes B]]
-[[Category: Frago, S.]]
+[[Category: Frago S]]
-[[Category: Hoppe, H.]]
+[[Category: Hoppe H]]
-[[Category: Jones, E Yvonne.]]
+[[Category: Jones EY]]
-[[Category: Prince, S N.]]
+[[Category: Prince SN]]
-[[Category: Rezgui, D.]]
+[[Category: Rezgui D]]
-[[Category: Rezgui, M.]]
+[[Category: Rezgui M]]
-[[Category: Wattana-Amorn, P.]]
+[[Category: Wattana-Amorn P]]
-[[Category: Williams, C.]]
+[[Category: Williams C]]
-[[Category: Zaccheo, O J.]]
+[[Category: Zaccheo OJ]]
-[[Category: Genomic imprinting]]
-[[Category: Insulin-like growth factor 2]]
-[[Category: Mannose 6 phosphate receptor]]
-[[Category: Protein evolution]]
-[[Category: Signaling protein]]