3odv: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-{{Seed}}
-[[Image:3odv.jpg|left|200px]]
-<!--
+==X-ray structure of kaliotoxin by racemic protein crystallography==
-The line below this paragraph, containing "STRUCTURE_3odv", creates the "Structure Box" on the page.
+<StructureSection load='3odv' size='340' side='right'caption='[[3odv]], [[Resolution|resolution]] 0.95&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3odv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Androctonus_mauritanicus_mauritanicus Androctonus mauritanicus mauritanicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ODV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ODV FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 0.95&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=TFA:TRIFLUOROACETIC+ACID'>TFA</scene></td></tr>
-{{STRUCTURE_3odv|  PDB=3odv  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3odv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3odv OCA], [https://pdbe.org/3odv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3odv RCSB], [https://www.ebi.ac.uk/pdbsum/3odv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3odv ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/KAX31_ANDMA KAX31_ANDMA] Potent inhibitor of large conductance calcium-activated potassium channels (BK-Ca). Also binds to the dendrotoxin sensitive voltage-dependent potassium channel. It appears to block channel activity by a simple bimolecular inhibition process. Induces a transient period of fast flickering in the channel openings, followed by an almost complete blockade of the channel. Its binding affinity to rat brain synaptosomes is 5-fold higher than this of KTX-3. Binding of the toxin to the channel is associated with significant structural rearrangements in both molecules.
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Here we report the total synthesis of kaliotoxin by 'one pot' native chemical ligation of three synthetic peptides. A racemic mixture of d- and l-kaliotoxin synthetic protein molecules gave crystals in the centrosymmetric space group P1[combining macron] that diffracted to atomic-resolution (0.95 A), enabling the X-ray structure of kaliotoxin to be determined by direct methods.
-===X-ray structure of kaliotoxin by racemic protein crystallography===
+Total chemical synthesis and X-ray structure of kaliotoxin by racemic protein crystallography.,Pentelute BL, Mandal K, Gates ZP, Sawaya MR, Yeates TO, Kent SB Chem Commun (Camb). 2010 Sep 28. PMID:20877851<ref>PMID:20877851</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 3odv" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_20877851}}, adds the Publication Abstract to the page
+*[[Potassium channel toxin 3D structures|Potassium channel toxin 3D structures]]
-(as it appears on PubMed at http://www.pubmed.gov), where 20877851 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_20877851}}
+__TOC__
+</StructureSection>
-==About this Structure==
+[[Category: Androctonus mauritanicus mauritanicus]]
-ODV is a 2 chains structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ODV OCA].
+[[Category: Large Structures]]
+[[Category: Gates ZP]]
-==Reference==
+[[Category: Kent SBH]]
-<ref group="xtra">PMID:20877851</ref><references group="xtra"/>
+[[Category: Mandal K]]
-[[Category: Gates, Z P.]]
+[[Category: Pentelute BL]]
-[[Category: Kent, S B.H.]]
+[[Category: Sawaya MR]]
-[[Category: Mandal, K.]]
+[[Category: Yeates TO]]
-[[Category: Pentelute, B L.]]
-[[Category: Sawaya, M R.]]
-[[Category: Yeates, T O.]]
-[[Category: Chemical synthesis]]
-[[Category: Direct method]]
-[[Category: Racemic protein]]
-[[Category: Toxin]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Oct 20 06:39:01 2010''