2l1k: Difference between revisions

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-[[Image:2l1k.jpg|left|200px]]
-<!--
+==Mouse prion protein (121-231) containing the substitutions Y169A, Y225A, and Y226A==
-The line below this paragraph, containing "STRUCTURE_2l1k", creates the "Structure Box" on the page.
+<StructureSection load='2l1k' size='340' side='right'caption='[[2l1k]]' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[2l1k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L1K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L1K FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l1k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l1k OCA], [https://pdbe.org/2l1k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l1k RCSB], [https://www.ebi.ac.uk/pdbsum/2l1k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l1k ProSAT]</span></td></tr>
-{{STRUCTURE_2l1k|  PDB=2l1k  |  SCENE=  }}
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/PRIO_MOUSE PRIO_MOUSE] Note=Found in high quantity in the brain of humans and animals infected with degenerative neurological diseases such as kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc.
+== Function ==
+[https://www.uniprot.org/uniprot/PRIO_MOUSE PRIO_MOUSE] May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains.<ref>PMID:12732622</ref> <ref>PMID:16492732</ref> <ref>PMID:19242475</ref> <ref>PMID:19568430</ref>
-===Mouse prion protein (121-231) containing the substitutions Y169A, Y225A, and Y226A===
+==See Also==
+*[[Prion 3D structures|Prion 3D structures]]
+== References ==
-==About this Structure==
+<references/>
-[[2l1k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L1K OCA].
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Mus musculus]]
-[[Category: Christen, B.]]
+[[Category: Christen B]]
-[[Category: Damberger, F F.]]
+[[Category: Damberger FF]]
-[[Category: Hornemann, S.]]
+[[Category: Hornemann S]]
-[[Category: Perez, D R.]]
+[[Category: Perez DR]]
-[[Category: Wuthrich, K.]]
+[[Category: Wuthrich K]]
-[[Category: Membrane protein]]
-[[Category: Mutation]]
-[[Category: Prion]]