2l1k: Difference between revisions
New page: '''Unreleased structure''' The entry 2l1k is ON HOLD Authors: Christen, B., Damberger, F.F., Perez, D.R., Hornemann, S., Wuthrich, K. Description: Mouse prion protein (121-231) with th... |
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==Mouse prion protein (121-231) containing the substitutions Y169A, Y225A, and Y226A== | |||
<StructureSection load='2l1k' size='340' side='right'caption='[[2l1k]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2l1k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L1K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L1K FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l1k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l1k OCA], [https://pdbe.org/2l1k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l1k RCSB], [https://www.ebi.ac.uk/pdbsum/2l1k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l1k ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/PRIO_MOUSE PRIO_MOUSE] Note=Found in high quantity in the brain of humans and animals infected with degenerative neurological diseases such as kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/PRIO_MOUSE PRIO_MOUSE] May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains.<ref>PMID:12732622</ref> <ref>PMID:16492732</ref> <ref>PMID:19242475</ref> <ref>PMID:19568430</ref> | |||
==See Also== | |||
*[[Prion 3D structures|Prion 3D structures]] | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | |||
[[Category: Christen B]] | |||
[[Category: Damberger FF]] | |||
[[Category: Hornemann S]] | |||
[[Category: Perez DR]] | |||
[[Category: Wuthrich K]] | |||