2l1e: Difference between revisions

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 == Structural highlights ==
 <table><tr><td colspan='2'>[[2l1e]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L1E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L1E FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l1e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l1e OCA], [https://pdbe.org/2l1e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l1e RCSB], [https://www.ebi.ac.uk/pdbsum/2l1e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l1e ProSAT]</span></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l1e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l1e OCA], [https://pdbe.org/2l1e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l1e RCSB], [https://www.ebi.ac.uk/pdbsum/2l1e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l1e ProSAT]</span></td></tr>
 </table>
-== Disease ==
-[https://www.uniprot.org/uniprot/PRIO_MOUSE PRIO_MOUSE] Note=Found in high quantity in the brain of humans and animals infected with degenerative neurological diseases such as kuru, Creutzfeldt-Jakob disease (CJD), Gerstmann-Straussler syndrome (GSS), scrapie, bovine spongiform encephalopathy (BSE), transmissible mink encephalopathy (TME), etc.
-== Function ==
-[https://www.uniprot.org/uniprot/PRIO_MOUSE PRIO_MOUSE] May play a role in neuronal development and synaptic plasticity. May be required for neuronal myelin sheath maintenance. May play a role in iron uptake and iron homeostasis. Soluble oligomers are toxic to cultured neuroblastoma cells and induce apoptosis (in vitro) (By similarity). Association with GPC1 (via its heparan sulfate chains) targets PRNP to lipid rafts. Also provides Cu(2+) or ZN(2+) for the ascorbate-mediated GPC1 deaminase degradation of its heparan sulfate side chains.<ref>PMID:12732622</ref> <ref>PMID:16492732</ref> <ref>PMID:19242475</ref> <ref>PMID:19568430</ref>
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 == Publication Abstract from PubMed ==