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[[Ferritin]] (FR) is an iron storage and release protein.  It stores iron as microcrystals with phosphate and hydroxide ions. FR is composed of 24 subunits of heavy chain (FTH) and light chain (FTL).<ref>PMID:20304033</ref>  Amphibians have an additional middle subunit FR (FTM).<br />
[[Ferritin]] (FR) is an iron storage and release protein.  It stores iron as microcrystals with phosphate and hydroxide ions. FR is composed of 24 subunits of heavy chain (FTH) and light chain (FTL).<ref>PMID:20304033</ref>  Amphibians have an additional middle subunit FR (FTM).<br />
*  '''Bacterioferritin''' (BFR) structure is very similar to FR.  It contains a binuclear iron center and haem.  It stores iron as ferric oxide mineral in its hollow central cavity.<br />
*  '''apo-ferritin''' (apo-FR) is a non-Fe-containing ferritin.<br />
*  '''Bacterioferritin''' (BFR) structure is very similar to FR.  It contains a binuclear iron center and haem.  It stores iron as ferric oxide mineral in its hollow central cavity<ref>PMID:37375226</ref>.<br />
*  '''Thioferritin''' (TFR) is a ferritin-related protein with 2 cysteine residues adjacent to the dimetal binding site.<br />
*  '''Thioferritin''' (TFR) is a ferritin-related protein with 2 cysteine residues adjacent to the dimetal binding site.<br />
*  Another iron storing protein is the '''DNA-binding Protein of Starved cells''' (Dps) - a ferritin-like diiron carboxylate.<br />
*  '''DNA-binding Protein of Starved cells''' (Dps) - a ferritin-like diiron carboxylate which acts as a molecular chaperone and may confer thermotolerance in ''E. coli''<ref>PMID:37229826</ref>.<br />
*  '''MrgA''' – another iron storage protein - belongs to the Dps family.


== Relevance ==
== Relevance ==
Line 19: Line 19:


==3D Structures of Ferritin==
==3D Structures of Ferritin==
[[Ferritin 3D structures]]


</StructureSection>
</StructureSection>
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
{{#tree:id=OrganizedByTopic|openlevels=0|


*Ferritin


**[[2jd6]], [[2jd7]] – PfFR - ''Pyrococcus furiosus'' <br />
**[[3a68]] – soFR from gene SferH4 – soybean<br />
**[[3a9q]] - soFR from gene SferH4 (mutant) <br />
**[[3egm]], [[3bve]], [[3bvf]], [[3bvi]], [[3bvk]], [[3bvl]] – HpFR – ''Heliobacter pylori''<br />
**[[1z4a]], [[1vlg]] – FR – ''Thermotoga maritime''<br />
**[[1s3q]], [[1sq3]], [[3kx9]], [[5v5k]] – FR – ''Archaeoglubus fulgidus''<br />
**[[1krq]] – FR – ''Campylobacter jejuni''<br />
**[[1eum]]  - EcFR – ''Escherichia coli''<br />
**[[1qgh]] – LiFR - ''Listeria innocua''<br />
**[[3qz3]] - VcFR – ''Vibrio cholerae''<br / >
**[[3vnx]] – FR – ''Ulva pertusa''<br />
**[[4ism]], [[4isp]], [[4itt]], [[4itw]], [[4iwj]], [[4iwk]], [[4ixk]], [[3e6r]], [[3e6s]] – PnmFR – ''Pseudo-nitschia multiseries''<br />
**[[1z6o]] – FR – ''Trichoplusia ni''<br />
**[[5n5f]] – FR – ''Haliangium ochraceum''<br />
*Ferritin light chain (FTL)
**[[1lb3]], [[1h96]] – mFTL – mouse<br />
**[[3noz]], [[3np0]], [[3np2]], [[3o7r]] – hoFTL (mutant) - horse<br />
**[[3o7s]], [[3u90]] - hoFTL<br />
**[[4v1w]] – hoFTL – cryo EM<br />
**[[3rav]], [[3rd0]] – hoFTL + barbiturate
*Ferritin middle subunit (FTM)
**[[4das]], [[1mfr]], [[1bg7]] – bFTM - bullfrog<br />
**[[4p18]], [[5xhi]], [[5xhm]], [[5xhn]], [[5xho]] – bFTM (mutant) <br />
**[[4lpj]], [[4lqj]], [[4lqn]], [[4lqv]], [[4lyu]], [[4lyx]], [[4my7]], [[3rbc]], [[3rgd]] – bFTM + Fe <br />
**[[4mjy]], [[4ml5]], [[4mn9]], [[5j8w]], [[5j93]], [[5j9v]], [[5jac]] – bFTM (mutant) + Fe<br />
**[[4lqh]], [[1mfr]], [[3ka3]] – bFTM + Mg<br />
**[[4lpm]], [[4mku]], [[5j8s]], [[3se1]], [[3sh6]], [[3shx]] – bFTM (mutant) + Mg<br />
**[[3ka4]] – bFTM + Co<br />
**[[4lpn]], [[3ka8]], [[3ka6]], [[3ka9]] – bFTM (mutant) + Co<br />
**[[1bg7]] – bFTM + Ca<br />
**[[3re7]] – bFTM + Cu<br />
*Ferritin heavy subunit (FTH)
**[[2z6m]], [[1r03]], [[2fha]], [[5yi5]] – hFTH<br />
**[[5xb1]] – hFTH (mutant)<br />
**[[2z6o]] – FTH – ''Trichoplusia ni''<br />
*apo-ferritin (apo-FR)
**[[2x17]] – apo-PfFR+Ag <br />
**[[2jd8]] – apo-PfFR+Zn<br />
**[[3h7g]] – apo-hoFR+Au <br />
**[[1hrs]] - apo-hoFR+protoporphyrin<br />
**[[5c6f]] – apo-HpFR (mutant) + Fe <br />
**[[2clu]], [[2cn6]] - apo-hFR (mutant)+Zn - human<br />
**[[4reu]] – apo-EcFR + Fe<br />
**[[4xgs]] – apo-EcFR (mutant) + Fe2O2<br />
**[[4ztt]] – apo-EcFR (mutant) + Fe2O + Fe2 + Fe + O2<br />
**[[4zkh]], [[4zkw]], [[4zkx]], [[4zl5]], [[4zl6]], [[4zlw]], [[4zmc]] – PnmFR (mutant) + Fe<br />
**[[4cmy]] – FR + Fe – ''Chlorobaculum tepidum''<br />
**[[5wpn]] - apo-FR (mutant)+Zn – parchment tube worm<br />
*apo-ferritin light chain (apo-FTL)
**[[2zg7]], [[2z5p]], [[2z5q]], [[2z5r]], [[3fi6]], [[3af7]], [[5e2d]], [[5hqo]] – apo-hoFTL+Pd<br />
**[[2zg8]], [[2zg9]], [[3af8]], [[3af9]], [[3noz]], [[3np0]], [[3np2]] - apo-hoFTL (mutant)+Pd<br />
**[[6env]] – apo-hoFTL+Au<br />
**[[3o7s]], [[3wvw]] - apo-hoFTL+Ru<br />
**[[2zur]] - apo-hoFTL+Rh<br />
**[[3o7r]], [[3wvu]], [[3wvv]] - apo-hoFTL (mutant) + Ru<br />
**[[4z3b]] - apo-hoFTL + Mn<br />
**[[5axs]], [[5e1u]], [[5erj]], [[5erk]], [[5ix6]], [[5mij]], [[5mik]], [[2w0o]], [[3f32]], [[1ies]], [[1ier]], [[1dat]], [[1aew]], [[2g4h]], [[2za6]] - apo-hoFTL + Cd<br />
**[[5lg2]] - apo-hoFTL + Fe<br />
**[[5czu]] - apo-hoFTL (mutant) + Fe<br />
**[[3f33]], [[3f34]], [[3f35]], [[3f36]], [[3f37]], [[3f38]], [[3f39]] - apo-hoFTL+phenols<br />
**[[2v2i]], [[2v2j]] - apo-hoFTL+haemin<br />
**[[2gyd]] - apo-hoFTL+diaziflurane<br />
**[[1xz1]] - apo-hoFTL+halothane<br />
**[[1xz3]] - apo-hoFTL+isoflurane<br />
**[[1gwg]] - apo-hoFTL+I3<br />
**[[2v2l]], [[2v2m]], [[2v2n]], [[2v2o]], [[2v2p]], [[2v2r]], [[2v2s]] - apo-hoFTL (mutant)+haemin<br />
**[[2fg8]] – apo-hFTL + Cs<br />
**[[3kxu]], [[2ffx]], [[2fg4]] - apo-hFTL+ Cd<br />
**[[1fha]], [[5lg8]] - apo-hFTL+ Fe<br />
**[[4de6]] - apo-hoFTL + arachidonic acid<br />
**[[1rcc]], [[1rcd]], [[1rci]] – apo-bFTL+tartrate+Mg<br />
**[[1rce]], [[1rcg]] - apo-bFTL+tartrate+Mn<br />
*apo-ferritin heavy chain (apo-FTH)
**[[2za7]], [[2za8]] - apo-hoFTH (mutant) + Cd<br />
**[[5gu0]], [[5gu1]], [[5gu2]], [[5gu3]] - apo-hoFTH (mutant) + Cd<br />
**[[3erz]] – apo-hFTH+Hg<br />
**[[3es3]] - apo-hFTH+Au<br />
**[[6b8f]], [[4ykh]] – apo-hFTH+Fe<br />
**[[5vtd]] – apo-hFTH+ Co<br />
**[[5up7]] – apo-hFTH+ Ni<br />
**[[5n26]] – apo-hFTH+ Pt<br />
**[[5n27]] – apo-hFTH+ Mg<br />
**[[2cn7]] – apo-hFTH (mutant) + Ca<br />
**[[2chi]], [[2clu]], [[2cei]], [[2cih]], [[2cn6]], [[2iu2]] – apo-hFTH (mutant) + Zn<br />
**[[5up8]], [[5up9]] – apo-hFTH+ Zn + oxamate derivative<br />
**[[4oyn]], [[4y08]], [[4zjk]], [[5jkk]], [[5jkl]], [[5jkm]] – hFTH + Fe<br />
**[[2z6m]] – hFTH + Zn<br />
**[[5cmq]], [[5cmr]] - hFTH (mutant) + Zn<br />
**[[1r03]], [[3ajo]] – hFTH + Mg<br />
**[[2fha]] – hFTH + Ca<br />
**[[4dyx]], [[4dyy]], [[4dyz]], [[4dz0]] - hFTH (mutant) + Cu<br />
**[[3ajp]], [[3ajq]] - hFTH (mutant) + Mg<br />
**[[3wnw]] – mFTH + Fe<br />
*Ferritin light+heavy chains
**[[5gn8]] – hFTH + Ca<br />
*Bacterioferritin (BFR)
**[[3gvy]] – BFR – ''Rhodobacter sphaeroides''<br />
**[[1jgc]] - BFR – ''Rhodobacter capsulatus''<br />
**[[1ji4]] – BFR – ''Helicobacter pylori''<br />
**[[1nf4]], [[1nf6]], [[1nfv]] – BFR – ''Desulfovibrio desulfuricans''<br />
**[[3fvb]] – BmBFR - ''Brucelia melitensis''<br />
**[[2fkz]], [[2fl0]], [[1sof]] – BFR – ''Azotobacrter vinelandii''<br />
**[[2wtl]], [[3qb9]], [[3uof]], [[3uoi]] – BFR – ''Mycobacterium tuberculosis''<br />
**[[3bkn]] - MsBFR – ''Mycobacterium smegmatis''<br />
**[[3is7]], [[3is8]], [[3ise]], [[3isf]], [[3r2h]], [[3r2k]], [[3r2l]], [[3r2m]], [[3r2o]], [[3r2r]], [[3r2s]] – BFR – ''Pseudomonas aeruginosa''<br />
**[[1bfr]], [[1bcf]], [[2htn]], [[2vxi]], [[3e1j]], [[3e1l]], [[3e1m]], [[3e1n]], [[3e1p]], [[3e1o]], [[3e1q]], [[2y3q]]  – EcBFR <br />
**[[3e2c]], [[4cvr]], [[4cvt]] – EcBFR (mutant) + Zn<br />
**[[4cvp]], [[3ghq]] - EcBFR (mutant) + Fe<br />
**[[4cvs]] – EcBFR (mutant) + Cd<br />
**[[4am2]], [[4am4]], [[4am5]] – BFR + Fe – ''Blastochloris viridis''
*Thioferritin (TFR)
**[[2vzb]] – TFR – ''Bacterioides fragilis''
*DNA-binding Protein of Starved cells (Dps)
**[[3iq1]] – VcDps <br />
**[[3ge4]] – BmDps <br />
**[[2iy4]] – Dps + Fe – ''Listeria monocytogenes''<br />
**[[2bkc]], [[2bk6]], [[2bjy]] – LiDps (mutant) <br />
**[[2f7n]] – Dps + Co – ''Deinococcus radiodurans''<br />
**[[4a25]] - Dps + Mn – ''Kinecoccus radiodurans''<br />
**[[1tjo]], [[1tk6]], [[1tkp]], [[1tko]], [[1moj]] – Dps + Fe – ''Halobacterium salinarum''<br />
**[[1o9r]] – Dps + Fe – ''Agrobacterium tumefaciens''<br />
**[[1dps]], [[1f33]] – EcDps <br />
**[[1f30]] – EcDps + Zn<br />
**[[1jre]] – EcDps + Cd<br />
**[[1jts]], [[1l8h]], [[1l8i]] – EcDps (mutant)<br />
**[[2ux1]] – SsDps + Zn – ''Streptococcus suis''<br />
**[[2v15]] – SsDps + Te<br />
**[[2xjm]] – SsDps + Co<br />
**[[2xjn]] – SsDps + Cu<br />
**[[2xjo]] – SsDps + Ni<br />
**[[2xkq]] – SsDps + Mn<br />
**[[2yw6]], [[2yw7]] – MsDps<br />
**[[3ak8]], [[3ak9]] – Dps + Mg – ''Salmonella enterica''<br />
**[[1n1q]] – Dps + Fe2O– ''Brevibacillus brevis''<br />
**[[1vei]], [[1vel]], [[1veq]] – MsDps + Fe <br />
**[[4dyu]] – Dps + Zn – ''Yersinia pestis''<br />
**[[5hjf]], [[5hjh]] - NpDps – ''Nostoc punctiforme''<br />
**[[5i4j]] - NpDps + Zn <br />
**[[5h4h]] - NpDps + Fe <br />
*MrgA
**[[2chp]] – MrgA – ''Bacillus subtilis''<br />
}}
== References ==
== References ==
<references/>
<references/>


[[Category:Topic Page]]
[[Category:Topic Page]]

Latest revision as of 09:35, 23 June 2024


Function

Ferritin (FR) is an iron storage and release protein. It stores iron as microcrystals with phosphate and hydroxide ions. FR is composed of 24 subunits of heavy chain (FTH) and light chain (FTL).[1] Amphibians have an additional middle subunit FR (FTM).

  • apo-ferritin (apo-FR) is a non-Fe-containing ferritin.
  • Bacterioferritin (BFR) structure is very similar to FR. It contains a binuclear iron center and haem. It stores iron as ferric oxide mineral in its hollow central cavity[2].
  • Thioferritin (TFR) is a ferritin-related protein with 2 cysteine residues adjacent to the dimetal binding site.
  • DNA-binding Protein of Starved cells (Dps) - a ferritin-like diiron carboxylate which acts as a molecular chaperone and may confer thermotolerance in E. coli[3].

Relevance

Cavities formed by FR are used for the manufacture of nanoparticles. FR is used as a marker for iron overload disorder.

Disease

FR deficiency can lead to anemia.

3D Structures of Ferritin

Ferritin 3D structures


Crystal structure of Fe-soaked ferritin from the hyperthermophilic archael anaerobe Pyrococcus furiousus 2jd7

Drag the structure with the mouse to rotate


ReferencesReferences

  1. ↑ Wang W, Knovich MA, Coffman LG, Torti FM, Torti SV. Serum ferritin: Past, present and future. Biochim Biophys Acta. 2010 Aug;1800(8):760-9. doi: 10.1016/j.bbagen.2010.03.011. , Epub 2010 Mar 19. PMID:20304033 doi:http://dx.doi.org/10.1016/j.bbagen.2010.03.011
  2. ↑ van der Ven AM, Gyamfi H, Suttisansanee U, Ahmad MS, Su Z, Taylor RM, Poole A, Chiorean S, Daub E, Urquhart T, Honek JF. Molecular Engineering of E. coli Bacterioferritin: A Versatile Nanodimensional Protein Cage. Molecules. 2023 Jun 9;28(12):4663. PMID:37375226 doi:10.3390/molecules28124663
  3. ↑ Park JH, Lee ES, Jung YJ. Functional characterization of the DNA-binding protein from starved cells (DPS) as a molecular chaperone under heat stress. Biochem Biophys Res Commun. 2023 Jul 30;667:180-185. PMID:37229826 doi:10.1016/j.bbrc.2023.05.064

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