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<applet load='Pdb2jd7.pdb' size='350' frame='true' align='right' scene="Ferritin/Starting_ferritin_scene/1" caption="Crystal structure of Fe-soaked ferritin from the hyperthermophilic archael anaerobe ''Pyrococcus furiousus'', [[2jd7]]" />
<StructureSection load='' size='400' side='right' caption="Crystal structure of Fe-soaked ferritin from the hyperthermophilic archael anaerobe ''Pyrococcus furiousus'' [[2jd7]]" scene='Ferritin/Starting_ferritin_scene/1'>
 
 
== Function ==
== Function ==


[[Ferritin]] (FR) is an iron storage and release protein.  It stores iron as microcrystals with phosphate and hydroxide ions. FR is composed of 24 subunits of heavy chain (FTH) and light chain (FTL).<ref>PMID:20304033</ref>  Amphibians have an additional middle subunit FR (FTM).<br />
[[Ferritin]] (FR) is an iron storage and release protein.  It stores iron as microcrystals with phosphate and hydroxide ions. FR is composed of 24 subunits of heavy chain (FTH) and light chain (FTL).<ref>PMID:20304033</ref>  Amphibians have an additional middle subunit FR (FTM).<br />
*  '''Bacterioferritin''' (BFR) structure is very similar to FR.  It contains a binuclear iron center and haem.  It stores iron as ferric oxide mineral in its hollow central cavity.<br />
*  '''apo-ferritin''' (apo-FR) is a non-Fe-containing ferritin.<br />
*  '''Bacterioferritin''' (BFR) structure is very similar to FR.  It contains a binuclear iron center and haem.  It stores iron as ferric oxide mineral in its hollow central cavity<ref>PMID:37375226</ref>.<br />
*  '''Thioferritin''' (TFR) is a ferritin-related protein with 2 cysteine residues adjacent to the dimetal binding site.<br />
*  '''Thioferritin''' (TFR) is a ferritin-related protein with 2 cysteine residues adjacent to the dimetal binding site.<br />
*  Another iron storing protein is the '''DNA-binding Protein of Starved cells''' (Dps) - a ferritin-like diiron carboxylate.<br />
*  '''DNA-binding Protein of Starved cells''' (Dps) - a ferritin-like diiron carboxylate which acts as a molecular chaperone and may confer thermotolerance in ''E. coli''<ref>PMID:37229826</ref>.<br />
*  '''MrgA''' – another iron storage protein - belongs to the Dps family.


== Relevance ==
== Relevance ==
Line 17: Line 19:


==3D Structures of Ferritin==
==3D Structures of Ferritin==
[[Ferritin 3D structures]]


Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
</StructureSection>
{{#tree:id=OrganizedByTopic|openlevels=0|
 
*Ferritin
 
**[[2jd6]], [[2jd7]] – PfFR - ''Pyrococcus furiosus'' <br />
**[[2jd8]] – PfFR+Zn<br />
**[[3a68]] – soFR from gene SferH4 – soybean<br />
**[[3a9q]] - soFR from gene SferH4 (mutant) <br />
**[[3egm]], [[3bvf]], [[3bvi]], [[3bvk]], [[3bvl]] – HpFR – ''Heliobacter pylori''<br />
**[[5c6f]] – HpFR (mutant) + Fe <br />
**[[1z4a]], [[1vlg]] – FR – ''Thermotoga maritime''<br />
**[[1s3q]], [[1sq3]], [[3kx9]] – FR – ''Archaeoglubus fulgidus''<br />
**[[1krq]] – FR – ''Campylobacter jejuni''<br />
**[[1eum]]  - EcFR – ''Escherichia coli''<br />
**[[4reu]] – EcFR + Fe<br />
**[[4xgs]] – EcFR (mutant) + Fe2O2<br />
**[[4ztt]] – EcFR (mutant) + Fe2O + Fe2 + Fe + O2<br />
**[[1qgh]] – LiFR - ''Listeria innocua''<br />
**[[3qz3]] - VcFR – ''Vibrio cholerae''<br / >
**[[3vnx]] – FR – ''Ulva pertusa''<br />
**[[4ism]], [[4isp]], [[4itt]], [[4itw]], [[4iwj]], [[4iwk]], [[4ixk]], [[3e6s]] – PnmFR – ''Pseudo-nitschia multiseries''<br />
**[[4zkh]], [[4zkw]], [[4zkx]], [[4zl5]], [[4zl6]], [[4zlw]], [[4zmc]] – PnmFR (mutant) + Fe<br />
**[[1z6o]] – FR – ''Trichoplusia ni''<br />
**[[4cmy]] – FR + Fe – ''Chlorobaculum tepidum''<br />
 
*Ferritin light chain (FTL)
 
**[[1lb3]], [[1h96]] – mFTL – mouse<br />
**[[1rcc]], [[1rcd]], [[1rci]] – bFTL+tartrate+Mg<br />
**[[1rce]], [[1rcg]] - bFTL+tartrate+Mn<br />
**[[3noz]], [[3np0]], [[3np2]], [[3o7r]] – hoFTL (mutant) - horse<br />
**[[3o7s]], [[3u90]] - hoFTL<br />
**[[4v1w]] – hoFTL – cryo EM<br />
**[[3rav]], [[3rd0]] – hoFTL + barbiturate
 
*Ferritin middle subunit (FTM)
 
**[[4das]] – bFTM - bullfrog<br />
**[[4p18]] – bFTM (mutant) <br />
**[[4lpj]], [[4lqj]], [[4lqn]], [[4lqv]], [[4lyu]], [[4lyx]], [[4my7]], [[3rbc]], [[3rgd]] – bFTM + Fe <br />
**[[4mjy]], [[4ml5]], [[4mn9]], [[5j8w]], [[5j93]], [[5j9v]], [[5jac]] – bFTM (mutant) + Fe<br />
**[[4lqh]], [[1mfr]], [[3ka3] – bFTM + Mg<br />
**[[4lpm]], [[4mku]], [[5j8s]], [[3se1]], [[3sh6]], [[3shx]] – bFTM (mutant) + Mg<br />
**[[3ka4]] – bFTM + Co<br />
**[[4lpn]], [[3ka8]], [[3ka6]], [[3ka9]] – bFTM (mutant) + Co<br />
**[[1bg7]] – bFTM + Ca<br />
**[[3re7]] – bFTM + Cu<br />
 
*apo-ferritin (apo-FR)
 
**[[2x17]] – apo-PfFR+Ag <br />
**[[3h7g]] – apo-hoFR+Au <br />
**[[1hrs]] - apo-hoFR+protoporphyrin<br />
**[[3bve]] – apo-HpFR<br />
**[[3e6r]] – apo-PnFR <br />
**[[2clu]], [[2cn6]] - apo-hFR (mutant)+Zn - human<br />
 
*apo-ferritin light chain (apo-FTL)
 
**[[2zg7]], [[2z5p]], [[2z5q]], [[2z5r]], [[3fi6]], [[3af7]], [[5e2d]], [[5hqo]] – apo-hoFTL+Pd<br />
**[[2zg8]], [[2zg9]], [[3af8]], [[3af9]], [[3noz]], [[3np0]], [[3np2]] - apo-hoFTL (mutant)+Pd<br />
**[[3o7s]], [[3wvw]] - apo-hoFTL+Ru<br />
**[[3o7r]], [[3wvu]], [[3wvv]] - apo-hoFTL (mutant) + Ru<br />
**[[4z3b]] - apo-hoFTL + Mn<br />
**[[5axs]], [[5e1u]], [[5erj]], [[5erk]], [[5ix6]], [[5mij]], [[5mik]] - apo-hoFTL + Cd<br />
**[[5lg2]] - apo-hoFTL + Fe<br />
**[[5czu]] - apo-hoFTL (mutant) + Fe<br />
**[[3f33]], [[3f34]], [[3f35]], [[3f36]], [[3f37]], [[3f38]], [[3f39]] - apo-hoFTL+phenols<br />
**[[2v2i]], [[2v2j]] - apo-hoFTL+haemin<br />
**[[2gyd]] - apo-hoFTL+diaziflurane<br />
**[[1xz1]] - apo-hoFTL+halothane<br />
**[[1xz3]] - apo-hoFTL+isoflurane<br />
**[[1gwg]] - apo-hoFTL+I3<br />
**[[2v2l]], [[2v2m]], [[2v2n]], [[2v2o]], [[2v2p]], [[2v2r]], [[2v2s]] - apo-hoFTL (mutant)+haemin<br />
**[[2za6]], [[2g4h]], [[1aew]], [[1dat]], [[1ier]], [[1ies]], [[3f32]], [[2zur]], [[2w0o]] - apo-hoFTL<br />
**[[2fg8]] – apo-hFTL + Cs<br />
**[[3kxu]], [[2ffx]], [[2fg4]] - apo-hFTL+ Cd<br />
**[[1fha]], [[5lg8]] - apo-hFTL+ Fe<br />
**[[4de6]] - apo-hoFTL + arachidonic acid
 
*apo-ferritin heavy chain (apo-FTH)
 
**[[2za7]], [[2za8]], [[2cn7]], [[2chi]], [[2clu]] - apo-hoFTH (mutant) <br />
**[[2cei]], [[2cih]], [[2cn6]], [[2iu2]] - apo-hoFTH (mutant)+Zn<br />
**[[5gu0]], [[5gu1]], [[5gu2]], [[5gu3]] - apo-hoFTH (mutant) + Cd<br />
**[[3erz]] – apo-hFR+Hg<br />
**[[3es3]] - apo-hFR+Au<br />
**[[5gou]] – hFTH <br />
**[[4oyn]], [[4y08]], [[4zjk]], [[5jkk]], [[5jkl]], [[5jkm]] – hFTH + Fe<br />
**[[2z6m]] – hFTH + Zn<br />
**[[5cmq]], [[5cmr]] - hFTH (mutant) + Zn<br />
**[[1r03]], [[3ajo]] – hFTH + Mg<br />
**[[2fha]] – hFTH + Ca<br />
**[[4dyx]], [[4dyy]], [[4dyz]], [[4dz0]] - hFTH (mutant) + Cu<br />
**[[3ajp]], [[3ajq]] - hFTH (mutant) + Mg<br />
**[[3wnw]] – mFTH + Fe<br />
 
*Ferritin light+heavy chains
 
**[[5gn8]] – hFTH + Ca<br />
 
*Bacterioferritin (BFR)
 
**[[3gvy]] – BFR – ''Rhodobacter sphaeroides''<br />
**[[1jgc]] - BFR – ''Rhodobacter capsulatus''<br />
**[[1ji4]] – BFR – ''Helicobacter pylori''<br />
**[[1nf4]], [[1nf6]], [[1nfv]] – BFR – ''Desulfovibrio desulfuricans''<br />
**[[3fvb]] – BmBFR - ''Brucelia melitensis''<br />
**[[2fkz]], [[2fl0]], [[1sof]] – BFR – ''Azotobacrter vinelandii''<br />
**[[2wtl]], [[3qb9]], [[3uof]], [[3uoi]] – BFR – ''Mycobacterium tuberculosis''<br />
**[[3bkn]] - MsBFR – ''Mycobacterium smegmatis''<br />
**[[3is7]], [[3is8]], [[3ise]], [[3isf]], [[3r2h]], [[3r2k]], [[3r2l]], [[3r2m]], [[3r2o]], [[3r2r]], [[3r2s]] – BFR – ''Pseudomonas aeruginosa''<br />
**[[1bfr]], [[1bcf]], [[2htn]], [[2vxi]], [[3e1j]], [[3e1l]], [[3e1m]], [[3e1n]], [[3e1p]], [[3e1o]], [[3e1q]], [[2y3q]]  – EcBFR <br />
**[[3e2c]], [[4cvr]], [[4cvt]] – EcBFR (mutant) + Zn<br />
**[[4cvp]], [[3ghq]] - EcBFR (mutant) + Fe<br />
**[[4cvs]] – EcBFR (mutant) + Cd<br />
**[[4am2]], [[4am4]], [[4am5]] – BFR + Fe – ''Blastochloris viridis''
 
*Thioferritin (TFR)
 
**[[2vzb]] – TFR – ''Bacterioides fragilis''
 
*DNA-binding Protein of Starved cells (Dps)
 
**[[3iq1]] – VcDps <br />
**[[3ge4]] – BmDps <br />
**[[2iy4]] – Dps + Fe – ''Listeria monocytogenes''<br />
**[[2bkc]], [[2bk6]], [[2bjy]] – LiDps (mutant) <br />
**[[2f7n]] – Dps + Co – ''Deinococcus radiodurans''<br />
**[[4a25]] - Dps + Mn – ''Kinecoccus radiodurans''<br />
**[[1tjo]], [[1tk6]], [[1tkp]], [[1tko]], [[1moj]] – Dps + Fe – ''Halobacterium salinarum''<br />
**[[1o9r]] – Dps + Fe – ''Agrobacterium tumefaciens''<br />
**[[1dps]], [[1f33]] – EcDps <br />
**[[1f30]] – EcDps + Zn<br />
**[[1jre]] – EcDps + Cd<br />
**[[1jts]], [[1l8h]], [[1l8i]] – EcDps (mutant)<br />
**[[2ux1]] – SsDps + Zn – ''Streptococcus suis''<br />
**[[2v15]] – SsDps + Te<br />
**[[2xjm]] – SsDps + Co<br />
**[[2xjn]] – SsDps + Cu<br />
**[[2xjo]] – SsDps + Ni<br />
**[[2xkq]] – SsDps + Mn<br />
**[[2yw6]], [[2yw7]] – MsDps<br />
**[[3ak8]], [[3ak9]] – Dps + Mg – ''Salmonella enterica''<br />
**[[1n1q]] – Dps + Fe2O– ''Brevibacillus brevis''<br />
**[[1vei]], [[1vel]], [[1veq]] – MsDps + Fe <br />
**[[4dyu]] – Dps + Zn – ''Yersinia pestis''<br />
**[[5hjf]] - NpDps – ''Nostoc punctiforme''<br />
**[[5i4j]] - NpDps + Zn <br />
**[[5h4h]] - NpDps + Fe <br />


*MrgA


**[[2chp]] – MrgA – ''Bacillus subtilis''<br />
}}
== References ==
== References ==
<references/>
<references/>


[[Category:Topic Page]]
[[Category:Topic Page]]

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David Canner, Eran Hodis, Alexander Berchansky, Michal Harel, Joel L. Sussman
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