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| | <StructureSection load='' size='400' side='right' caption="Crystal structure of Fe-soaked ferritin from the hyperthermophilic archael anaerobe ''Pyrococcus furiousus'' [[2jd7]]" scene='Ferritin/Starting_ferritin_scene/1'> |
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| <applet load='Pdb2jd7.pdb' size='400' frame='true' align='right' scene="Ferritin/Starting_ferritin_scene/1" caption="Crystal structure of Fe-soaked ferritin from the hyperthermophilic archael anaerobe ''Pyrococcus furiousus'', [[2jd7]]" />
| | == Function == |
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| [[Ferritin]] (FR) is an iron storage and release protein. It stores iron as microcrystals with phosphate and hydroxide ions. FR is composed of 24 subunits of heavy chain (FTH) and light chain (FTL).<br /> | | [[Ferritin]] (FR) is an iron storage and release protein. It stores iron as microcrystals with phosphate and hydroxide ions. FR is composed of 24 subunits of heavy chain (FTH) and light chain (FTL).<ref>PMID:20304033</ref> Amphibians have an additional middle subunit FR (FTM).<br /> |
| * '''Bacterioferritin''' (BFR) structure is very similar to FR. It contains a binuclear iron center and haem. It stores iron as ferric oxide mineral in its hollow central cavity.<br /> | | * '''apo-ferritin''' (apo-FR) is a non-Fe-containing ferritin.<br /> |
| | * '''Bacterioferritin''' (BFR) structure is very similar to FR. It contains a binuclear iron center and haem. It stores iron as ferric oxide mineral in its hollow central cavity<ref>PMID:37375226</ref>.<br /> |
| * '''Thioferritin''' (TFR) is a ferritin-related protein with 2 cysteine residues adjacent to the dimetal binding site.<br /> | | * '''Thioferritin''' (TFR) is a ferritin-related protein with 2 cysteine residues adjacent to the dimetal binding site.<br /> |
| * Another iron storing protein is the '''DNA-binding Protein of Starved cells''' (Dps).<br /> | | * '''DNA-binding Protein of Starved cells''' (Dps) - a ferritin-like diiron carboxylate which acts as a molecular chaperone and may confer thermotolerance in ''E. coli''<ref>PMID:37229826</ref>.<br /> |
| * '''MrgA''' – another iron storage protein - belongs to the Dps family.
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| ==3D Structures of Ferritin== | | == Relevance == |
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
| | Cavities formed by FR are used for the manufacture of nanoparticles. FR is used as a marker for iron overload disorder. |
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| ===Ferritin=== | | == Disease == |
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| [[2jd6]], [[2jd7]] – PfFR - ''Pyrococcus furiosus'' <br />
| | FR deficiency can lead to anemia. |
| [[2jd8]] – PfFR+Zn<br />
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| [[3kxu]] – hFR (mutant) – human<br />
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| [[3hx2]], [[3hx5]], [[3hx7]], [[1fha]] - hFR<br />
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| [[3a68]] – soFR from gene SferH4 – soybean<br />
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| [[3a9q]] - soFR from gene SferH4 (mutant) <br />
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| [[3egm]], [[3bvf]], [[3bvi]], [[3bvk]], [[3bvl]] – HpFR – ''Heliobacter pylori''<br />
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| [[3e6s]] - PnFR – Pseudo-nitzschia<br />
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| [[1z4a]], [[1vlg]] – FR – ''Thermotoga maritime''<br />
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| [[1s3q]], [[1sq3]], [[3kx9]] – FR – ''Archaeoglubus fulgidus''<br />
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| [[1krq]] – FR – ''Campylobacter jejuni''<br />
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| [[1eum]] - EcFR – ''Escherichia coli''<br />
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| [[1qgh]] – LiFR - ''Listeria innocua''<br />
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| [[1mfr]], [[1bg7]], [[3ka3]], [[3ka4]], [[3rbc]], [[3re7]], [[3rgd]], [[4das]] – bFR - Bullfrog<br />
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| [[3ka6]], [[3ka8]], [[3ka9]] – bFR (mutant)+Co<br />
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| [[3se1]], [[3sh6]], [[3shx]] - bFR (mutant) + Mg<br />
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| [[3qz3]] - VcFR – ''Vibrio cholerae''<br / >
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| [[3vnx]] – FR – ''Ulva pertusa''<br />
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| [[4ism]], [[4isp]], [[4itt]], [[4itw]], [[4iwj]], [[4iwk]], [[4ixk]] – FR – ''Pseudo-nitschia multiseries''<br />
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| [[1z6o]] – FTH – ''Trichoplusia ni''<br />
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| ===Ferritin light chain (FTL) === | | ==3D Structures of Ferritin== |
| | | [[Ferritin 3D structures]] |
| [[1lb3]], [[1h96]] – FTL – mouse<br />
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| [[1rcc]], [[1rcd]], [[1rci]] – bFTL+tartrate+Mg<br />
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| [[1rce]], [[1rcg]] - bFTL+tartrate+Mn<br />
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| [[3noz]], [[3np0]], [[3np2]], [[3o7r]] – hoFTL (mutant) - horse<br /> | |
| [[3o7s]], [[3u90]] - hoFTL<br />
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| [[3rav]], [[3rd0]] – hoFTL + barbiturate
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| ===Ferritin heavy chain (FTH) ===
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| [[2z6m]], [[1r03]], [[2fha]], [[3ajo]] – hFTH<br />
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| [[3ajp]], [[3ajq]], [[4dyx]], [[4dyy]], [[4dyz]], [[4dz0]] - hFTH (mutant)<br />
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| ===apo-ferritin (apo-FR) ===
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| [[2x17]] – apo-PfFR+Ag <br />
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| [[3h7g]] – apo-hoFR+Au <br />
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| [[1hrs]] - apo-hoFR+protoporphyrin<br />
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| [[3bve]] – apo-HpFR<br />
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| [[3e6r]] – apo-PnFR <br />
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| [[2clu]], [[2cn6]] - apo-hFR (mutant)+Zn<br />
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| ===apo-ferritin light chain (apo-FTL) ===
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| [[2zg7]], [[2z5p]], [[2z5q]], [[2z5r]], [[3fi6]], [[3af7]] – apo-hoFTL+Pd<br />
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| [[2zg8]], [[2zg9]], [[3af8]], [[3af9]] - apo-hoFTL (mutant)+Pd<br />
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| [[3f33]], [[3f34]], [[3f35]], [[3f36]], [[3f37]], [[3f38]], [[3f39]] - apo-hoFTL+phenols<br />
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| [[2v2i]], [[2v2j]] - apo-hoFTL+haemin<br />
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| [[2gyd]] - apo-hoFTL+diaziflurane<br />
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| [[1xz1]] - apo-hoFTL+halothane<br />
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| [[1xz3]] - apo-hoFTL+isoflurane<br />
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| [[1gwg]] - apo-hoFTL+I3<br />
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| [[2v2l]], [[2v2m]], [[2v2n]], [[2v2o]], [[2v2p]], [[2v2r]], [[2v2s]] - apo-hoFTL (mutant)+haemin<br />
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| [[2za6]], [[2g4h]], [[1aew]], [[1dat]], [[1ier]], [[1ies]], [[3f32]], [[2zur]], [[2w0o]] - apo-hoFTL<br />
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| [[2ffx]], [[2fg4]], [[2fg8]] – apo-hFTL<br />
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| [[4de6]] - apo-hoFTL + arachidonic acid
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| ===apo-ferritin heavy chain (apo-FTH) ===
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| [[2za7]], [[2za8]], [[2cn7]], [[2chi]], [[2clu]] - apo-hoFTH (mutant) <br />
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| [[2cei]], [[2cih]], [[2cn6]], [[2iu2]] - apo-hoFTH (mutant)+Zn<br />
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| [[3erz]] – apo-hFR+Hg<br />
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| [[3es3]] - apo-hFR+Au<br />
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| ===Bacterioferritin (BFR) ===
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| [[3gvy]] – BFR – ''Rhodobacter sphaeroides''<br />
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| [[1jgc]] - BFR – ''Rhodobacter capsulatus''<br />
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| [[1ji4]] – BFR – ''Helicobacter pylori''<br />
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| [[1nf4]], [[1nf6]], [[1nfv]] – BFR – ''Desulfovibrio desulfuricans''<br />
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| [[3fvb]] – BmBFR - ''Brucelia melitensis''<br />
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| [[2fkz]], [[2fl0]], [[1sof]] – BFR – ''Azotobacrter vinelandii''<br />
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| [[2wtl]], [[3qb9]], [[3uof]], [[3uoi]] – BFR – ''Mycobacterium tuberculosis''<br />
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| [[3bkn]] - MsBFR – ''Mycobacterium smegmatis''<br />
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| [[3is7]], [[3is8]], [[3ise]], [[3isf]], [[3r2h]], [[3r2k]], [[3r2l]], [[3r2m]], [[3r2o]], [[3r2r]], [[3r2s]] – BFR – ''Pseudomonas aeruginosa''<br />
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| [[1bfr]], [[1bcf]], [[2htn]], [[2vxi]], [[3e1j]], [[3e1l]], [[3e1m]], [[3e1n]], [[3e1p]], [[3e1o]], [[3e1q]], [[2y3q]] – EcBFR <br />
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| [[3e2c]], [[3ghq]] – EcBFR (mutant)<br />
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| [[4am2]], [[4am4]], [[4am5]] – BFR – ''Blastochloris viridis''
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| ===Thioferritin (TFR) ===
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| [[2vzb]] – TFR – ''Bacterioides fragilis''
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| ===DNA-binding Protein of Starved cells (Dps) ===
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| [[3iq1]] – VcDps <br />
| | </StructureSection> |
| [[3ge4]] – BmDps <br />
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| [[2iy4]] – Dps – ''Listeria monocytogenes''<br />
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| [[2bkc]], [[2bk6]], [[2bjy]] – LiDps (mutant) <br />
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| [[2f7n]] – Dps – ''Deinococcus radiodurans''<br />
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| [[1tjo]], [[1tk6]], [[1tkp]], [[1tko]], [[1moj]] – Dps – ''Halobacterium salinarum''<br />
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| [[1o9r]] – Dps – ''Agrobacterium tumefaciens''<br />
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| [[1dps]], [[1f30]], [[1f33]], [[1jre]] – EcDps <br />
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| [[1jts]], [[1l8h]], [[1l8i]] – EcDps (mutant)<br />
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| [[2ux1]], [[2v15]], [[2xjm]], [[2xjn]], [[2xjo]], [[2xkq]] – Dps – ''Streptococcus suis''<br />
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| [[2yw6]] – MsDps<br />
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| [[3ak8]], [[3ak9]] – Dps – ''Salmonella enterica''<br />
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| [[1n1q]] – Dps – ''Brevibacillus brevis''<br />
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| [[1vei]], [[1vel]], [[1veq]], [[2yw7]] – MsDps<br />
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| [[4dyu]] – Dpo – ''Yersinia pestis''
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| ===MrgA===
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| [[2chp]] – MrgA – ''Bacillus subtilis''<br />
| | == References == |
| | <references/> |
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| [[Category:Topic Page]] | | [[Category:Topic Page]] |