|
|
| (35 intermediate revisions by 2 users not shown) |
| Line 1: |
Line 1: |
| [[Image:2jd73.png|thumb|left|250px|Crystal structure of ferritin from ''Pyrococcs Furiousus'' ([[2jd7]])]]
| | <StructureSection load='' size='400' side='right' caption="Crystal structure of Fe-soaked ferritin from the hyperthermophilic archael anaerobe ''Pyrococcus furiousus'' [[2jd7]]" scene='Ferritin/Starting_ferritin_scene/1'> |
|
| |
|
| <applet load='Pdb2jd7.pdb' size='400' frame='true' align='right' scene="Ferritin/Starting_ferritin_scene/1" caption="Crystal structure of Fe-soaked ferritin from the hyperthermophilic archael anaerobe ''Pyrococcus furiousus'', [[2jd7]]" />
| |
|
| |
|
| | == Function == |
|
| |
|
| | [[Ferritin]] (FR) is an iron storage and release protein. It stores iron as microcrystals with phosphate and hydroxide ions. FR is composed of 24 subunits of heavy chain (FTH) and light chain (FTL).<ref>PMID:20304033</ref> Amphibians have an additional middle subunit FR (FTM).<br /> |
| | * '''apo-ferritin''' (apo-FR) is a non-Fe-containing ferritin.<br /> |
| | * '''Bacterioferritin''' (BFR) structure is very similar to FR. It contains a binuclear iron center and haem. It stores iron as ferric oxide mineral in its hollow central cavity<ref>PMID:37375226</ref>.<br /> |
| | * '''Thioferritin''' (TFR) is a ferritin-related protein with 2 cysteine residues adjacent to the dimetal binding site.<br /> |
| | * '''DNA-binding Protein of Starved cells''' (Dps) - a ferritin-like diiron carboxylate which acts as a molecular chaperone and may confer thermotolerance in ''E. coli''<ref>PMID:37229826</ref>.<br /> |
|
| |
|
| | == Relevance == |
|
| |
|
| | Cavities formed by FR are used for the manufacture of nanoparticles. FR is used as a marker for iron overload disorder. |
|
| |
|
| | == Disease == |
|
| |
|
| | | FR deficiency can lead to anemia. |
| | |
| | |
| | |
| | |
| | |
| | |
| | |
| | |
| | |
| | |
| | |
| | |
| | |
| | |
| | |
| | |
| | |
| | |
| [[Ferritin]] (FR) is an iron storage and release protein. It stores iron as microcrystals with phosphate and hydroxide ions. FR is composed of 24 subunits of heavy chain (FTH) and light chain (FTL). '''Bacterioferritin''' (BFR) structure is very similar to FR. It contains a binuclear iron center and haem. It stores iron as ferric oxide mineral in its hollow central cavity. '''Thioferritin''' (TFR) is a ferritin-related protein with 2 cysteine residues adjacent to the dimetal binding site. Another iron storing protein is the '''DNA-binding Protein of Starved cells''' (Dps). '''MrgA''' – another iron storage protein - belongs to the Dps family.
| |
|
| |
|
| ==3D Structures of Ferritin== | | ==3D Structures of Ferritin== |
| | [[Ferritin 3D structures]] |
|
| |
|
| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
| | </StructureSection> |
| | |
| ===Ferritin===
| |
| | |
| [[2jd6]], [[2jd7]] – PfFR - ''Pyrococcus furiosus'' <br />
| |
| [[2jd8]] – PfFR+Zn<br />
| |
| [[3kxu]] – hFR (mutant) – human<br />
| |
| [[3hx2]], [[3hx5]], [[3hx7]], [[1fha]] - hFR<br />
| |
| [[3a68]] – soFR from gene SferH4 – soybean<br />
| |
| [[3a9q]] - soFR from gene SferH4 (mutant) <br />
| |
| [[3egm]], [[3bvf]], [[3bvi]], [[3bvk]], [[3bvl]] – HpFR – ''Heliobacter pylori''<br />
| |
| [[3e6s]] - PnFR – Pseudo-nitzschia<br />
| |
| [[1z4a]], [[1vlg]] – FR – ''Thermotoga maritime''<br />
| |
| [[1s3q]], [[1sq3]], [[3kx9]] – FR – ''Archaeoglubus fulgidus''<br />
| |
| [[1krq]] – FR – ''Campylobacter jejuni''<br />
| |
| [[1eum]] - EcFR – ''Escherichia coli''<br />
| |
| [[1qgh]] – LiFR - ''Listeria innocua''<br />
| |
| [[1mfr]], [[1bg7]], [[3ka3]], [[3ka4]], [[3rbc]], [[3re7]], [[3rgd]], [[4das]] – bFR - Bullfrog<br />
| |
| [[3ka6]], [[3ka8]], [[3ka9]] – bFR (mutant)+Co<br />
| |
| [[3se1]], [[3sh6]], [[3shx]] - bFR (mutant) + Mg<br />
| |
| [[3qz3]] - VcFR – ''Vibrio cholerae''<br / >
| |
| [[3vnx]] – FR – ''Ulva pertusa''<br />
| |
| [[4ism]], [[4isp]], [[4itt]], [[4itw]], [[4iwj]], [[4iwk]], [[4ixk]] – FR – ''Pseudo-nitschia multiseries''<br />
| |
| | |
| ===Ferritin light chain (FTL) ===
| |
| | |
| [[1lb3]], [[1h96]] – FTL – mouse<br />
| |
| [[1rcc]], [[1rcd]], [[1rci]] – bFTL+tartrate+Mg<br />
| |
| [[1rce]], [[1rcg]] - bFTL+tartrate+Mn<br />
| |
| [[3noz]], [[3np0]], [[3np2]], [[3o7r]] – hoFTL (mutant) - horse<br />
| |
| [[3o7s]], [[3u90]] - hoFTL<br />
| |
| [[3rav]], [[3rd0]] – hoFTL + barbiturate
| |
| | |
| ===Ferritin heavy chain (FTH) ===
| |
| | |
| [[2z6m]], [[1r03]], [[2fha]], [[3ajo]] – hFTH<br />
| |
| [[3ajp]], [[3ajq]], [[4dyx]], [[4dyy]], [[4dyz]], [[4dz0]] - hFTH (mutant)<br />
| |
| [[2z6o]] – FTH – ''Trichoplusia ni''<br />
| |
| | |
| ===apo-ferritin (apo-FR) ===
| |
| | |
| [[2x17]] – apo-PfFR+Ag <br />
| |
| [[3h7g]] – apo-hoFR+Au <br />
| |
| [[1hrs]] - apo-hoFR+protoporphyrin<br />
| |
| [[3bve]] – apo-HpFR<br />
| |
| [[3e6r]] – apo-PnFR <br />
| |
| [[2clu]], [[2cn6]] - apo-hFR (mutant)+Zn<br />
| |
| | |
| ===apo-ferritin light chain (apo-FTL) ===
| |
| | |
| [[2zg7]], [[2z5p]], [[2z5q]], [[2z5r]], [[3fi6]], [[3af7]] – apo-hoFTL+Pd<br />
| |
| [[2zg8]], [[2zg9]], [[3af8]], [[3af9]] - apo-hoFTL (mutant)+Pd<br />
| |
| [[3f33]], [[3f34]], [[3f35]], [[3f36]], [[3f37]], [[3f38]], [[3f39]] - apo-hoFTL+phenols<br />
| |
| [[2v2i]], [[2v2j]] - apo-hoFTL+haemin<br />
| |
| [[2gyd]] - apo-hoFTL+diaziflurane<br />
| |
| [[1xz1]] - apo-hoFTL+halothane<br />
| |
| [[1xz3]] - apo-hoFTL+isoflurane<br />
| |
| [[1gwg]] - apo-hoFTL+I3<br />
| |
| [[2v2l]], [[2v2m]], [[2v2n]], [[2v2o]], [[2v2p]], [[2v2r]], [[2v2s]] - apo-hoFTL (mutant)+haemin<br />
| |
| [[2za6]], [[2g4h]], [[1aew]], [[1dat]], [[1ier]], [[1ies]], [[3f32]], [[2zur]], [[2w0o]] - apo-hoFTL<br />
| |
| [[2ffx]], [[2fg4]], [[2fg8]] – apo-hFTL<br />
| |
| [[4de6]] - apo-hoFTL + arachidonic acid
| |
| | |
| ===apo-ferritin heavy chain (apo-FTH) ===
| |
| | |
| [[2za7]], [[2za8]], [[2cn7]], [[2chi]], [[2clu]] - apo-hoFTH (mutant) <br />
| |
| [[2cei]], [[2cih]], [[2cn6]], [[2iu2]] - apo-hoFTH (mutant)+Zn<br />
| |
| [[3erz]] – apo-hFR+Hg<br />
| |
| [[3es3]] - apo-hFR+Au<br />
| |
| | |
| ===Bacterioferritin (BFR) ===
| |
| | |
| [[3gvy]] – BFR – ''Rhodobacter sphaeroides''<br />
| |
| [[1jgc]] - BFR – ''Rhodobacter capsulatus''<br />
| |
| [[1ji4]] – BFR – ''Helicobacter pylori''<br />
| |
| [[1nf4]], [[1nf6]], [[1nfv]] – BFR – ''Desulfovibrio desulfuricans''<br />
| |
| [[3fvb]] – BmBFR - ''Brucelia melitensis''<br />
| |
| [[2fkz]], [[2fl0]], [[1sof]] – BFR – ''Azotobacrter vinelandii''<br />
| |
| [[2wtl]], [[3qb9]], [[3uof]], [[3uoi]] – BFR – ''Mycobacterium tuberculosis''<br />
| |
| [[3bkn]] - MsBFR – ''Mycobacterium smegmatis''<br />
| |
| [[3is7]], [[3is8]], [[3ise]], [[3isf]], [[3r2h]], [[3r2k]], [[3r2l]], [[3r2m]], [[3r2o]], [[3r2r]], [[3r2s]] – BFR – ''Pseudomonas aeruginosa''<br />
| |
| [[1bfr]], [[1bcf]], [[2htn]], [[2vxi]], [[3e1j]], [[3e1l]], [[3e1m]], [[3e1n]], [[3e1p]], [[3e1o]], [[3e1q]], [[2y3q]] – EcBFR <br />
| |
| [[3e2c]], [[3ghq]] – EcBFR (mutant)<br />
| |
| [[4am2]], [[4am4]], [[4am5]] – BFR – ''Blastochloris viridis''
| |
| | |
| ===Thioferritin (TFR) ===
| |
| | |
| [[2vzb]] – TFR – ''Bacterioides fragilis''
| |
| | |
| ===DNA-binding Protein of Starved cells (Dps) ===
| |
| | |
| [[3iq1]] – VcDps <br />
| |
| [[3ge4]] – BmDps <br />
| |
| [[2iy4]] – Dps – ''Listeria monocytogenes''<br />
| |
| [[2bkc]], [[2bk6]], [[2bjy]] – LiDps (mutant) <br />
| |
| [[2f7n]] – Dps – ''Deinococcus radiodurans''<br />
| |
| [[1tjo]], [[1tk6]], [[1tkp]], [[1tko]], [[1moj]] – Dps – ''Halobacterium salinarum''<br />
| |
| [[1o9r]] – Dps – ''Agrobacterium tumefaciens''<br />
| |
| [[1dps]], [[1f30]], [[1f33]], [[1jre]] – EcDps <br />
| |
| [[1jts]], [[1l8h]], [[1l8i]] – EcDps (mutant)<br />
| |
| [[2ux1]], [[2v15]], [[2xjm]], [[2xjn]], [[2xjo]], [[2xkq]] – Dps – ''Streptococcus suis''<br />
| |
| [[2yw6]] – MsDps<br />
| |
| [[3ak8]], [[3ak9]] – Dps – ''Salmonella enterica''<br />
| |
| [[1n1q]] – Dps – ''Brevibacillus brevis''<br />
| |
| [[1vei]], [[1vel]], [[1veq]], [[2yw7]] – MsDps<br />
| |
| [[4dyu]] – Dpo – ''Yersinia pestis''
| |
|
| |
|
| ===MrgA===
| |
|
| |
|
| [[2chp]] – MrgA – ''Bacillus subtilis''<br />
| | == References == |
| | <references/> |
|
| |
|
| [[Category:Topic Page]] | | [[Category:Topic Page]] |