3nku: Difference between revisions

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-{{Seed}}
-[[Image:3nku.jpg|left|200px]]
-<!--
+==Crystal structure of the N-terminal domain of DrrA/SidM from Legionella pneumophila==
-The line below this paragraph, containing "STRUCTURE_3nku", creates the "Structure Box" on the page.
+<StructureSection load='3nku' size='340' side='right'caption='[[3nku]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3nku]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Legionella_pneumophila_subsp._pneumophila_str._Philadelphia_1 Legionella pneumophila subsp. pneumophila str. Philadelphia 1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NKU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NKU FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
-{{STRUCTURE_3nku|  PDB=3nku  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3nku FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3nku OCA], [https://pdbe.org/3nku PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3nku RCSB], [https://www.ebi.ac.uk/pdbsum/3nku PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3nku ProSAT]</span></td></tr>
+</table>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+In the course of Legionnaires' disease, the bacterium Legionella pneumophila affects the intracellular vesicular trafficking of infected eukaryotic cells by recruiting the small guanosine triphosphatase (GTPase) Rab1 to the cytosolic face of the Legionella-containing vacuole. In order to accomplish this, the Legionella protein DrrA contains a specific guanine nucleotide exchange activity for Rab1 activation that exchanges guanosine triphosphate (GTP) for guanosine diphosphate on Rab1. We found that the amino-terminal domain of DrrA possesses adenosine monophosphorylation (AMPylation) activity toward the switch II region of Rab1b, leading to posttranslational covalent modification of tyrosine 77. AMPylation of switch II by DrrA restricts the access of GTPase activating proteins, thereby rendering Rab1b constitutively active.
-===Crystal structure of the N-terminal domain of DrrA/SidM from Legionella pneumophila===
+The Legionella effector protein DrrA AMPylates the membrane traffic regulator Rab1b.,Muller MP, Peters H, Blumer J, Blankenfeldt W, Goody RS, Itzen A Science. 2010 Aug 20;329(5994):946-9. Epub 2010 Jul 22. PMID:20651120<ref>PMID:20651120</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-<!--
+</div>
-The line below this paragraph, {{ABSTRACT_PUBMED_20651120}}, adds the Publication Abstract to the page
+<div class="pdbe-citations 3nku" style="background-color:#fffaf0;"></div>
-(as it appears on PubMed at http://www.pubmed.gov), where 20651120 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_20651120}}
+__TOC__
+</StructureSection>
-==About this Structure==
+[[Category: Large Structures]]
-NKU is a 2 chains structure with sequences from [http://en.wikipedia.org/wiki/Legionella_pneumophila_subsp._pneumophila Legionella pneumophila subsp. pneumophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NKU OCA].
+[[Category: Legionella pneumophila subsp. pneumophila str. Philadelphia 1]]
+[[Category: Blankenfeldt W]]
-==Reference==
+[[Category: Goody RS]]
-<ref group="xtra">PMID:20651120</ref><references group="xtra"/>
+[[Category: Itzen A]]
-[[Category: Legionella pneumophila subsp. pneumophila]]
+[[Category: Mueller MP]]
-[[Category: Blankenfeldt, W.]]
+[[Category: Peters H]]
-[[Category: Goody, R S.]]
-[[Category: Itzen, A.]]
-[[Category: Mueller, M P.]]
-[[Category: Peters, H.]]
-[[Category: Adenylylation]]
-[[Category: Ampylation]]
-[[Category: Drra]]
-[[Category: Posttranslational modification]]
-[[Category: Protein transport]]
-[[Category: Rab1]]
-[[Category: Rab1b]]
-[[Category: Sidm]]
-[[Category: Vesicular transport]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Aug  4 09:12:45 2010''