3ncc: Difference between revisions

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 ==A human Prolactin receptor antagonist in complex with the mutant extracellular domain H188A of the human prolactin receptor==
-<StructureSection load='3ncc' size='340' side='right' caption='[[3ncc]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
+<StructureSection load='3ncc' size='340' side='right'caption='[[3ncc]], [[Resolution|resolution]] 2.50&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[3ncc]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NCC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3NCC FirstGlance]. <br>
+<table><tr><td colspan='2'>[[3ncc]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3NCC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3NCC FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5&#8491;</td></tr>
-<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3mzg|3mzg]], [[3n06|3n06]], [[3n0p|3n0p]], [[3ncb|3ncb]], [[3nce|3nce]], [[3ncf|3ncf]]</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CO3:CARBONATE+ION'>CO3</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">hPRL, PRL ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]), hPRLr, PRLR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ncc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ncc OCA], [https://pdbe.org/3ncc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ncc RCSB], [https://www.ebi.ac.uk/pdbsum/3ncc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ncc ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3ncc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ncc OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3ncc RCSB], [http://www.ebi.ac.uk/pdbsum/3ncc PDBsum]</span></td></tr>
 </table>
+== Function ==
+[https://www.uniprot.org/uniprot/PRLR_HUMAN PRLR_HUMAN] This is a receptor for the anterior pituitary hormone prolactin (PRL). Isoform 4 is unable to transduce prolactin signaling. Isoform 6 is unable to transduce prolactin signaling.<ref>PMID:12580759</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
 Check<jmol>
    <jmolCheckbox>
-     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nc/3ncc_consurf.spt"</scriptWhenChecked>
+     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/nc/3ncc_consurf.spt"</scriptWhenChecked>
-     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
      <text>to colour the structure by Evolutionary Conservation</text>
    </jmolCheckbox>
-</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3ncc ConSurf].
 <div style="clear:both"></div>
 <div style="background-color:#fffaf0;">
@@ Line 26: / Line 28: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 3ncc" style="background-color:#fffaf0;"></div>
+==See Also==
+*[[Prolactin|Prolactin]]
+*[[Prolactin receptor|Prolactin receptor]]
 == References ==
 <references/>
@@ Line 31: / Line 38: @@
 </StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Chayen, N E]]
+[[Category: Large Structures]]
-[[Category: Hodsdon, M E]]
+[[Category: Chayen NE]]
-[[Category: Keeler, C]]
+[[Category: Hodsdon ME]]
-[[Category: Kulkarni, M V]]
+[[Category: Keeler C]]
-[[Category: Lolis, E J]]
+[[Category: Kulkarni MV]]
-[[Category: Murphy, J W]]
+[[Category: Lolis EJ]]
-[[Category: Myszka, D G]]
+[[Category: Murphy JW]]
-[[Category: Tettamanzi, M C]]
+[[Category: Myszka DG]]
-[[Category: Hematopoietic cytokine]]
+[[Category: Tettamanzi MC]]
-[[Category: Hormone-hormone receptor complex]]
-[[Category: Ph dependence]]