3n0l: Difference between revisions

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[[Image:3n0l.png|left|200px]]


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==Crystal structure of serine hydroxymethyltransferase from Campylobacter jejuni==
The line below this paragraph, containing "STRUCTURE_3n0l", creates the "Structure Box" on the page.
<StructureSection load='3n0l' size='340' side='right'caption='[[3n0l]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[3n0l]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Campylobacter_jejuni Campylobacter jejuni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N0L OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3N0L FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
-->
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
{{STRUCTURE_3n0l| PDB=3n0l |  SCENE= }}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3n0l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n0l OCA], [https://pdbe.org/3n0l PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3n0l RCSB], [https://www.ebi.ac.uk/pdbsum/3n0l PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3n0l ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GLYA_CAMJE GLYA_CAMJE] Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity).[HAMAP-Rule:MF_00051]
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n0/3n0l_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3n0l ConSurf].
<div style="clear:both"></div>


===Crystal structure of serine hydroxymethyltransferase from Campylobacter jejuni===
==See Also==
 
*[[Serine hydroxymethyltransferase 3D structures|Serine hydroxymethyltransferase 3D structures]]
 
__TOC__
==About this Structure==
</StructureSection>
[[3n0l]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Campylobacter_jejuni Campylobacter jejuni]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N0L OCA].
[[Category: Campylobacter jejuni]]
[[Category: Campylobacter jejuni]]
[[Category: Glycine hydroxymethyltransferase]]
[[Category: Large Structures]]
[[Category: Anderson, S M.]]
[[Category: Anderson SM]]
[[Category: Anderson, W F.]]
[[Category: Anderson WF]]
[[Category: CSGID, Center for Structural Genomics of Infectious Diseases.]]
[[Category: Hasseman J]]
[[Category: Hasseman, J.]]
[[Category: Onopriyenko O]]
[[Category: Onopriyenko, O.]]
[[Category: Savchenko A]]
[[Category: Savchenko, A.]]
[[Category: Wawrzak Z]]
[[Category: Wawrzak, Z.]]
[[Category: Alpha beta class]]
[[Category: Campylobacter]]
[[Category: Center for structural genomics of infectious disease]]
[[Category: Csgid]]
[[Category: Structural genomic]]
[[Category: Transferase]]

Latest revision as of 13:12, 6 November 2024

Crystal structure of serine hydroxymethyltransferase from Campylobacter jejuniCrystal structure of serine hydroxymethyltransferase from Campylobacter jejuni

Structural highlights

3n0l is a 2 chain structure with sequence from Campylobacter jejuni. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.8Å
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

GLYA_CAMJE Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism (By similarity).[HAMAP-Rule:MF_00051]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

3n0l, resolution 1.80Å

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
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