3n0t: Difference between revisions

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==Human dipeptidil peptidase DPP7 complexed with inhibitor GSK237826A==
==Human dipeptidil peptidase DPP7 complexed with inhibitor GSK237826A==
<StructureSection load='3n0t' size='340' side='right' caption='[[3n0t]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
<StructureSection load='3n0t' size='340' side='right'caption='[[3n0t]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3n0t]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N0T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3N0T FirstGlance]. <br>
<table><tr><td colspan='2'>[[3n0t]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3N0T OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3N0T FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=OPY:(3S)-4-OXO-4-PIPERIDIN-1-YLBUTANE-1,3-DIAMINE'>OPY</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3jyh|3jyh]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=OPY:(3S)-4-OXO-4-PIPERIDIN-1-YLBUTANE-1,3-DIAMINE'>OPY</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">DPP2, DPP7, QPP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3n0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n0t OCA], [https://pdbe.org/3n0t PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3n0t RCSB], [https://www.ebi.ac.uk/pdbsum/3n0t PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3n0t ProSAT]</span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dipeptidyl-peptidase_II Dipeptidyl-peptidase II], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.14.2 3.4.14.2] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3n0t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3n0t OCA], [http://pdbe.org/3n0t PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3n0t RCSB], [http://www.ebi.ac.uk/pdbsum/3n0t PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3n0t ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/DPP2_HUMAN DPP2_HUMAN]] Plays an important role in the degradation of some oligopeptides.<ref>PMID:15487984</ref>
[https://www.uniprot.org/uniprot/DPP2_HUMAN DPP2_HUMAN] Plays an important role in the degradation of some oligopeptides.<ref>PMID:15487984</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n0/3n0t_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/n0/3n0t_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
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==See Also==
==See Also==
*[[Dipeptidyl peptidase|Dipeptidyl peptidase]]
*[[Dipeptidyl peptidase 3D structures|Dipeptidyl peptidase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Dipeptidyl-peptidase II]]
[[Category: Homo sapiens]]
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Arrowsmith, C H]]
[[Category: Arrowsmith CH]]
[[Category: Bochkarev, A]]
[[Category: Bochkarev A]]
[[Category: Bountra, C]]
[[Category: Bountra C]]
[[Category: Cossar, D]]
[[Category: Cossar D]]
[[Category: Crombet, L]]
[[Category: Crombet L]]
[[Category: Dobrovetsky, E]]
[[Category: Dobrovetsky E]]
[[Category: Edwards, A M]]
[[Category: Edwards AM]]
[[Category: Haffner, C]]
[[Category: Haffner C]]
[[Category: Hassell, A]]
[[Category: Hassell A]]
[[Category: Khutoreskaya, G]]
[[Category: Khutoreskaya G]]
[[Category: Pagannon, S]]
[[Category: Pagannon S]]
[[Category: Structural genomic]]
[[Category: Seitova A]]
[[Category: Seitova, A]]
[[Category: Shewchuk L]]
[[Category: Shewchuk, L]]
[[Category: Weigelt J]]
[[Category: Weigelt, J]]
[[Category: Aminopeptidase]]
[[Category: Cleavage on pair of basic residue]]
[[Category: Cytoplasmic vesicle]]
[[Category: Glycoprotein]]
[[Category: Hydrolase]]
[[Category: Lysosome]]
[[Category: Protease]]
[[Category: Serine protease]]
[[Category: Sgc]]
[[Category: Zymogen]]

Latest revision as of 09:00, 17 October 2024

Human dipeptidil peptidase DPP7 complexed with inhibitor GSK237826AHuman dipeptidil peptidase DPP7 complexed with inhibitor GSK237826A

Structural highlights

3n0t is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.45Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

DPP2_HUMAN Plays an important role in the degradation of some oligopeptides.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Maes MB, Lambeir AM, Gilany K, Senten K, Van der Veken P, Leiting B, Augustyns K, Scharpe S, De Meester I. Kinetic investigation of human dipeptidyl peptidase II (DPPII)-mediated hydrolysis of dipeptide derivatives and its identification as quiescent cell proline dipeptidase (QPP)/dipeptidyl peptidase 7 (DPP7). Biochem J. 2005 Mar 1;386(Pt 2):315-24. PMID:15487984 doi:http://dx.doi.org/10.1042/BJ20041156

3n0t, resolution 2.45Å

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