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| {{STRUCTURE_7ahl| PDB=7ahl | SIZE=400| SCENE= |right|CAPTION=α-hemolysin heptamer, [[7ahl]] }}
| | <StructureSection load='7ahl' size='350' side='right' caption='α-hemolysin heptamer (PDB code [[7ahl]]).' scene=''> |
| | == Function == |
| | '''Hemolysin''' (HL) is exotoxin from bacteria which causes lysis of red blood cells<ref>PMID:20110774</ref>. |
| | *'''alpha-hemolysin''' is a transmembrane pore-forming heptameric molecule<ref>PMID:8943190</ref>. See details for in [[Pore forming toxin, α-hemolysin]]. |
| | *'''delta-hemolysin''' is a 26 amino acid peptide from the bacterium ''Staphylococcus'' exhibiting antimicrobial activity against'' Legionerlla'' <ref>PMID:19150639</ref>. |
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| '''Hemolysin''' (HL) is exotoxin from bacteria which causes lysis of red blood cells<ref>PMID:20110774</ref>. Hemolysin from the bacterium ''Clostridium'' are called '''alpha-toxin''' (AT). AT is a zinc metalloenzyme and binds to the membrane in the presence of calcium. It acts as a phospholipase C.
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| See details for α-hemolysin in [[Pore forming toxin, α-hemolysin]].
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| See details of hemolysin E in [[Molecular Playground/ClyA]]. | | See details of hemolysin E in [[Molecular Playground/ClyA]]. |
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| For toxins in Proteopdia see [[Toxins]]. | | For toxins in Proteopdia see [[Toxins]]. |
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| == 3D Structures of hemolysin == | | == Relevance == |
| | HL acts as a virulence factor in the pathogenesis of invasive infections<ref>PMID:12564994</ref>. |
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| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
| | ==3D Printed Physical Model of Hemolysin== |
| {{#tree:id=OrganizedByTopic|openlevels=0|
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| *α-hemolysin
| | Shown below is a 3D printed physical model of Hemolysin. The model is shown in alpha carbon backbone format with each chain colored uniquely. |
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| **[[3anz]], [[7ahl]] – SaHL-α – ''Staphylococcus aureus''<br />
| | [[Image:hemolysin1_centerForBioMolecularModeling.jpg|550px]] |
| A full page in Proteopedia exploring [[7ahl]] is found [[Pore_forming_toxin,_α-hemolsyin|here]].<br/>
| | [[Image:hemolysin2_centerForBioMolecularModeling.jpg|550px]] |
| **[[3m2l]], [[3m4d]], [[4p24]] - SaHL-α (mutant)<br />
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| **[[3m3r]], [[3m4e]] - SaHL-α (mutant) + β-cyclodextrin<br />
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| **[[4idj]], [[4u6v]] - SaHL-α + antibody<br />
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| *β-hemolysin
| | ====The MSOE Center for BioMolecular Modeling==== |
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| **[[3k55]] – SaHL-β)<br />
| | [[Image:CbmUniversityLogo.jpg | left | 150px]] |
| **[[3i5v]] - SaHL-β residues 35-330)<br />
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| **[[3i41]] - SaHL-β residues 35-330 (mutant)<br />
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| **[[3i46]], [[3i48]] - SaHL-β residues 35-330 (mutant)<br /> + metal ion
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| *γ-hemolysin
| | The [http://cbm.msoe.edu MSOE Center for BioMolecular Modeling] uses 3D printing technology to create physical models of protein and molecular structures, making the invisible molecular world more tangible and comprehensible. To view more protein structure models, visit our [http://cbm.msoe.edu/educationalmedia/modelgallery/ Model Gallery]. |
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| **[[2qk7]] – SaHL-γ component A (mutant) +B (mutant)<br />
| | == 3D Structures of hemolysin == |
| **[[3b07]] - SaHL-γ component A+B<br />
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| **[[4p1x]] - SaHL-γ component B (mutant)+C<br />
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| **[[4p1y]] - SaHL-γ component A + B (mutant)<br />
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| *δ-hemolysin
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| **[[2kam]] – SaHL-δ - NMR
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| *Hemolysin
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| **[[3o44]] – VcHL residues 161-741 – ''Vibrio cholerae''<br />
| | [[Hemolysin 3D structures]] |
| **[[1xez]] – VcHL (mutant)<br />
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| **[[3a57]] – HL 2 – ''Vibrio parahaemolyticus''<br />
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| **[[3hvn]] – HL (mutant) – ''Streptococcus suis''<br />
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| **[[3fy3]] – HL A residues 30-265 – ''Proteus mirabilis''<br />
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| **[[2wcd]] – EcHL E residues 2-303 – ''Escherichia coli''<br />
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| **[[1qoy]], [[4pho]], [[4phq]] - EcHL E (mutant)<br />
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| **[[1mt0]] – EcHL B ATP-binding domain<br />
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| **[[2oai]], [[2r8d]] – HL corc_hlyc domain – ''Xylella fastidiosa''<br />
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| **[[2r2z]] – HL residues 346-435 – ''Enterococcus faecalis''<br />
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| *Alpha-toxin
| | </StructureSection> |
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| **[[2wxt]], [[1ca1]] - CpAT + Cd + Zn – ''Clostridium perfringens''<br />
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| **[[1qm6]], [[1gyg]], [[1kho]] - CpAT + Zn <br />
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| **[[2wy6]], [[2wxu]] – CpAT (mutant) + Ca + Cd + Zn<br />
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| **[[1qmd]] - CpAT + Ca + Zn<br />
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| **[[1olp]] - AT + Ca + Zn – ''Clostridium absonum''<br />
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| **[[2vk9]] - AT – ''Clostridium novyi''<br />
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| }}
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| == References == | | == References == |
| <references/> | | <references/> |
| [[Category:Topic Page]] | | [[Category:Topic Page]] |