Hemolysin: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Wayne Decatur, Alexander Berchansky, Michal Harel, Mark Hoelzer

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-{{STRUCTURE_7ahl|  PDB=7ahl  | SIZE=400| SCENE= |right|CAPTION=α-hemolysin heptamer, [[7ahl]] }}
+<StructureSection load='7ahl' size='350' side='right' caption='α-hemolysin heptamer (PDB code [[7ahl]]).' scene=''>
+== Function ==
+'''Hemolysin''' (HL) is exotoxin from bacteria which causes lysis of red blood cells<ref>PMID:20110774</ref>.
+*'''alpha-hemolysin''' is a transmembrane pore-forming heptameric molecule<ref>PMID:8943190</ref>.  See details for in [[Pore forming toxin, α-hemolysin]].
+*'''delta-hemolysin''' is a 26 amino acid peptide from the bacterium ''Staphylococcus'' exhibiting antimicrobial activity against'' Legionerlla'' <ref>PMID:19150639</ref>.
-'''Hemolysin''' (HL) is exotoxin from bacteria which causes lysis of red blood cells.
+See details of hemolysin E in [[Molecular Playground/ClyA]].
-See details for α-hemolysin in [[Pore forming toxin, α-hemolysin]].
 For toxins in Proteopdia see [[Toxins]].
-== 3D Structures of hemolysin ==
+== Relevance ==
+HL acts as a virulence factor in the pathogenesis of invasive infections<ref>PMID:12564994</ref>.
-Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
-{{#tree:id=OrganizedByTopic|openlevels=0|
-*α-hemolysin
+==3D Printed Physical Model of Hemolysin==
-**[[3anz]], [[7ahl]] – SaHL-α – ''Staphylococcus aureus''<br />
+Shown below is a 3D printed physical model of Hemolysin. The model is shown in alpha carbon backbone format with each chain colored uniquely.
-A full page in Proteopedia exploring [[7ahl]] is found [[Pore_forming_toxin,_α-hemolsyin|here]].<br/>
-**[[3m2l]], [[3m4d]] - SaHL-α (mutant)<br />
-**[[3m3r]], [[3m4e]] - SaHL-α (mutant) + β-cyclodextrin<br />
-**[[4idj]] - SaHL-α + antibody<br />
-*β-hemolysin
+[[Image:hemolysin1_centerForBioMolecularModeling.jpg|550px]]
+[[Image:hemolysin2_centerForBioMolecularModeling.jpg|550px]]
-**[[3k55]] – SaHL-β)<br />
+====The MSOE Center for BioMolecular Modeling====
-**[[3i5v]] - SaHL-β residues 35-330)<br />
-**[[3i41]] - SaHL-β residues 35-330 (mutant)<br />
-**[[3i46]], [[3i48]] - SaHL-β residues 35-330 (mutant)<br /> + metal ion
-*γ-hemolysin
+[[Image:CbmUniversityLogo.jpg | left | 150px]]
-**[[2qk7]] – SaHL-γ (mutant)<br />
+The [http://cbm.msoe.edu MSOE Center for BioMolecular Modeling] uses 3D printing technology to create physical models of protein and molecular structures, making the invisible molecular world more tangible and comprehensible. To view more protein structure models, visit our [http://cbm.msoe.edu/educationalmedia/modelgallery/ Model Gallery].
-**[[3b07]] - SaHL-γ
-*δ-hemolysin
+== 3D Structures of hemolysin ==
-**[[2kam]] – SaHL-δ - NMR
+[[Hemolysin 3D structures]]
-*Hemolysin
+</StructureSection>
-**[[3o44]] – VcHL residues 161-741 – ''Vibrio cholerae''<br />
+== References ==
-**[[1xez]] – VcHL (mutant)<br />
+<references/>
-**[[3a57]] – HL 2 – ''Vibrio parahaemolyticus''<br />
-**[[3hvn]] – HL (mutant) – ''Streptococcus suis''<br />
-**[[3fy3]] – HL A residues 30-265 – ''Proteus mirabilis''<br />
-**[[2wcd]] – EcHL E residues 2-303 – ''Escherichia coli''<br />
-**[[1qoy]] - EcHL E (mutant)<br />
-**[[1mt0]] – EcHL B ATP-binding domain<br />
-**[[2oai]], [[2r8d]] – HL corc_hlyc domain – ''Xylella fastidiosa''<br />
-**[[2r2z]] – HL residues 346-435 – ''Enterococcus faecalis''
-}}
 [[Category:Topic Page]]