3maz: Difference between revisions

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OCA

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 ==Crystal Structure of the Human BRDG1/STAP-1 SH2 Domain in Complex with the NTAL pTyr136 Peptide==
-<StructureSection load='3maz' size='340' side='right' caption='[[3maz]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
+<StructureSection load='3maz' size='340' side='right'caption='[[3maz]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[3maz]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MAZ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3MAZ FirstGlance]. <br>
+<table><tr><td colspan='2'>[[3maz]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3MAZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3MAZ FirstGlance]. <br>
-</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
-<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MLI:MALONATE+ION'>MLI</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">STAP1, BRDG1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3maz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3maz OCA], [https://pdbe.org/3maz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3maz RCSB], [https://www.ebi.ac.uk/pdbsum/3maz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3maz ProSAT]</span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3maz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3maz OCA], [http://pdbe.org/3maz PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3maz RCSB], [http://www.ebi.ac.uk/pdbsum/3maz PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3maz ProSAT]</span></td></tr>
 </table>
-== Disease ==
-[[http://www.uniprot.org/uniprot/NTAL_HUMAN NTAL_HUMAN]] Williams syndrome. Note=LAT2 is located in the Williams-Beuren syndrome (WBS) critical region. WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of LAT2 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease.<ref>PMID:11124535</ref> <ref>PMID:11003705</ref> <ref>PMID:11124535</ref>
 == Function ==
-[[http://www.uniprot.org/uniprot/STAP1_HUMAN STAP1_HUMAN]] In BCR signaling, appears to function as a docking protein acting downstream of TEC and participates in a positive feedback loop by increasing the activity of TEC.<ref>PMID:10518561</ref>  [[http://www.uniprot.org/uniprot/NTAL_HUMAN NTAL_HUMAN]] Involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. May also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. Couples activation of these receptors and their associated kinases with distal intracellular events through the recruitment of GRB2.<ref>PMID:12486104</ref> <ref>PMID:12514734</ref> <ref>PMID:15010370</ref>
+[https://www.uniprot.org/uniprot/STAP1_HUMAN STAP1_HUMAN] In BCR signaling, appears to function as a docking protein acting downstream of TEC and participates in a positive feedback loop by increasing the activity of TEC.<ref>PMID:10518561</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 18: / Line 15: @@
    <jmolCheckbox>
      <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ma/3maz_consurf.spt"</scriptWhenChecked>
-     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
      <text>to colour the structure by Evolutionary Conservation</text>
    </jmolCheckbox>
@@ Line 36: / Line 33: @@
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
-[[Category: Huang, H]]
+[[Category: Large Structures]]
-[[Category: Kaneko, T]]
+[[Category: Huang H]]
-[[Category: Li, L]]
+[[Category: Kaneko T]]
-[[Category: Li, S S]]
+[[Category: Li L]]
-[[Category: Liu, H]]
+[[Category: Li SS]]
-[[Category: Schiller, M R]]
+[[Category: Liu H]]
-[[Category: Voss, C K]]
+[[Category: Schiller MR]]
-[[Category: Wu, C]]
+[[Category: Voss CK]]
-[[Category: Zhao, B]]
+[[Category: Wu C]]
-[[Category: Cytoplasm]]
+[[Category: Zhao B]]
-[[Category: Modular domain]]
-[[Category: Phosphoprotein]]
-[[Category: Phosphotyrosine]]
-[[Category: Sh2 domain]]
-[[Category: Signaling protein]]
-[[Category: Specificity]]