3m19: Difference between revisions

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-[[Image:3m19.png|left|200px]]
-<!--
+==Crystal structure of variable lymphocyte receptor VLRA.R5.1==
-The line below this paragraph, containing "STRUCTURE_3m19", creates the "Structure Box" on the page.
+<StructureSection load='3m19' size='340' side='right'caption='[[3m19]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[3m19]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Petromyzon_marinus Petromyzon marinus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M19 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3M19 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3m19 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3m19 OCA], [https://pdbe.org/3m19 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3m19 RCSB], [https://www.ebi.ac.uk/pdbsum/3m19 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3m19 ProSAT]</span></td></tr>
-{{STRUCTURE_3m19|  PDB=3m19  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/C7B6Z3_PETMA C7B6Z3_PETMA]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/m1/3m19_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3m19 ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Adaptive immunity in jawless vertebrates is mediated by leucine-rich repeat proteins called "variable lymphocyte receptors" (VLRs). Two types of VLR (A and B) are expressed by mutually exclusive lymphocyte populations in lamprey. VLRB lymphocytes resemble the B cells of jawed vertebrates; VLRA lymphocytes are similar to T cells. We determined the structure of a high-affinity VLRA isolated from lamprey immunized with hen egg white lysozyme (HEL) in unbound and antigen-bound forms. The VLRA-HEL complex demonstrates that certain VLRAs, like gammadelta T-cell receptors (TCRs) but unlike alphabeta TCRs, can recognize antigens directly, without a requirement for processing or antigen-presenting molecules. Thus, these VLRAs feature the nanomolar affinities of antibodies, the direct recognition of unprocessed antigens of both antibodies and gammadelta TCRs, and the exclusive expression on the lymphocyte surface that is unique to alphabeta and gammadelta TCRs.
-===Crystal structure of variable lymphocyte receptor VLRA.R5.1===
+A structural basis for antigen recognition by the T cell-like lymphocytes of sea lamprey.,Deng L, Velikovsky CA, Xu G, Iyer LM, Tasumi S, Kerzic MC, Flajnik MF, Aravind L, Pancer Z, Mariuzza RA Proc Natl Acad Sci U S A. 2010 Jul 8. PMID:20616002<ref>PMID:20616002</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-<!--
+</div>
-The line below this paragraph, {{ABSTRACT_PUBMED_20616002}}, adds the Publication Abstract to the page
+<div class="pdbe-citations 3m19" style="background-color:#fffaf0;"></div>
-(as it appears on PubMed at http://www.pubmed.gov), where 20616002 is the PubMed ID number.
--->
-{{ABSTRACT_PUBMED_20616002}}
-==About this Structure==
-[[3m19]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Petromyzon_marinus Petromyzon marinus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3M19 OCA].
 ==See Also==
-*[[Lamprey Variable Lymphocyte Receptor]]
+*[[Lamprey Variable Lymphocyte Receptor|Lamprey Variable Lymphocyte Receptor]]
+*[[Variable lymphocyte receptor 3D structures|Variable lymphocyte receptor 3D structures]]
-==Reference==
+== References ==
-<ref group="xtra">PMID:20616002</ref><references group="xtra"/>
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Petromyzon marinus]]
-[[Category: Deng, L.]]
+[[Category: Deng L]]
-[[Category: Mariuzza, R A.]]
+[[Category: Mariuzza RA]]
-[[Category: Velikovsky, C A.]]
+[[Category: Velikovsky CA]]
-[[Category: Adaptive immunity]]
-[[Category: Antibody]]
-[[Category: B cell]]
-[[Category: Immune system]]
-[[Category: Leucine-rich repeat]]
-[[Category: T cell]]
-[[Category: Variable lymphocyte receptor]]