5uz7: Difference between revisions

<StructureSection load='5uz7' size='340' side='right' caption='[[5uz7]], [[Resolution|resolution]] 4.10&Aring;' scene=''>

<table><tr><td colspan='2'>[[5uz7]] is a 5 chain structure with sequence from [http://en.wikipedia.org/wiki/Camelus_glama Camelus glama] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5UZ7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5UZ7 FirstGlance]. <br>

</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">GNAS, GNAS1, GSP ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), GNB1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), GNG2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN]), CALCR ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5uz7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5uz7 OCA], [http://pdbe.org/5uz7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5uz7 RCSB], [http://www.ebi.ac.uk/pdbsum/5uz7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5uz7 ProSAT]</span></td></tr>

[[http://www.uniprot.org/uniprot/GNAS2_HUMAN GNAS2_HUMAN]] Guanine nucleotide-binding proteins (G proteins) function as transducers in numerous signaling pathways controlled by G protein-coupled receptors (GPCRs) (PubMed:17110384). Signaling involves the activation of adenylyl cyclases, resulting in increased levels of the signaling molecule cAMP (PubMed:26206488, PubMed:8702665). GNAS functions downstream of several GPCRs, including beta-adrenergic receptors (PubMed:21488135). Stimulates the Ras signaling pathway via RAPGEF2 (PubMed:12391161).<ref>PMID:12391161</ref> <ref>PMID:17110384</ref> <ref>PMID:21488135</ref> <ref>PMID:26206488</ref> <ref>PMID:8702665</ref>  [[http://www.uniprot.org/uniprot/GBG2_HUMAN GBG2_HUMAN]] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction (By similarity). [[http://www.uniprot.org/uniprot/GBB1_HUMAN GBB1_HUMAN]] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.<ref>PMID:18611381</ref> [[http://www.uniprot.org/uniprot/CALCR_HUMAN CALCR_HUMAN]] This is a receptor for calcitonin. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The calcitonin receptor is thought to couple to the heterotrimeric guanosine triphosphate-binding protein that is sensitive to cholera toxin.

*[[Transducin|Transducin]]

</StructureSection>

[[Category: Camelus glama]]

[[Category: Human]]

[[Category: Baumeister, W]]

[[Category: Christopoulos, A]]

[[Category: Christopoulos, G]]

[[Category: Coudrat, T]]

[[Category: Danev, R]]

[[Category: Furness, S G.B]]

[[Category: Glukhova, A]]

[[Category: Khoshouei, M]]

[[Category: Kobilka, B K]]

[[Category: Liang, Y L]]

[[Category: Miller, L J]]

[[Category: Radjainia, M]]

[[Category: Sexton, P M]]

[[Category: Skiniotis, G]]

[[Category: Tarrasch, J]]

[[Category: Thal, D M]]

[[Category: Wootten, D]]

[[Category: Zhang, Y]]

[[Category: Signaling protein]]